TY - JOUR
T1 - Polygenic panels predicting the susceptibility of multiple upper aerodigestive tract cancer in oral cancer patients
AU - Chien, Huei Tzu
AU - Yeh, Chi Chin
AU - Young, Chi Kuang
AU - Chen, Tzu Ping
AU - Liao, Chun Ta
AU - Wang, Hung Ming
AU - Cho, Kai Lun
AU - Huang, Shiang Fu
N1 - Funding Information:
Funding: This study was supported by Grants CMRPG3H0793, CMRPG3J0592, and CMRPG3J0593 from Chang Gung Memorial Hospital and grant MOST 109-2314-B-182-015 from the Ministry of Science and Technology, Executive Yuan, Taiwan, ROC and by the Health and Welfare Surcharge on Tobacco Products (grants MOHW109-TDU-B-212-134016) from the Ministry of Health and Welfare (MOHW), Executive Yuan, Taiwan, ROC.
Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021/5
Y1 - 2021/5
N2 - Head and neck cancer was closely related with habitual use of cigarette and alcohol. Those cancer patients are susceptible to develop multiple primary tumors (MPTs). In this study, we utilized the single nucleotide polymorphisms (SNPs) array (Affymetrix Axion Genome-Wide TWB 2.0 Array Plate) to investigate patients’ risks of developing multiple primary cancers. We recruited 712 male head and neck cancer patients between Mar 1996 and Feb 2017. Two hundred and eighty-six patients (40.2%) had MPTs and 426 (59.8%) had single cancer. Four hundred and twelve normal controls were also recruited. A list of seventeen factors was extracted and ten factors were demonstrated to increase the risks of multiple primary cancers (alcohol drinking, rs118169127, rs149089400, rs76367287, rs61401220, rs141057871, rs7129229, older age, rs3760265, rs9554264; all were p value < 0.05). Polygenic scoring model was built and the area under curve to predict the risk developing MPTs is 0.906. Alcohol drinking, among the seventeen factors, was the most important risk factor to develop MPT in upper aerodigestive tract (OR: 7.071, 95% C.I.: 2.134–23.434). For those with high score in polygenic model, routine screening of upper digestive tract including laryngoscope and esophagoscope is suggested to detect new primaries early.
AB - Head and neck cancer was closely related with habitual use of cigarette and alcohol. Those cancer patients are susceptible to develop multiple primary tumors (MPTs). In this study, we utilized the single nucleotide polymorphisms (SNPs) array (Affymetrix Axion Genome-Wide TWB 2.0 Array Plate) to investigate patients’ risks of developing multiple primary cancers. We recruited 712 male head and neck cancer patients between Mar 1996 and Feb 2017. Two hundred and eighty-six patients (40.2%) had MPTs and 426 (59.8%) had single cancer. Four hundred and twelve normal controls were also recruited. A list of seventeen factors was extracted and ten factors were demonstrated to increase the risks of multiple primary cancers (alcohol drinking, rs118169127, rs149089400, rs76367287, rs61401220, rs141057871, rs7129229, older age, rs3760265, rs9554264; all were p value < 0.05). Polygenic scoring model was built and the area under curve to predict the risk developing MPTs is 0.906. Alcohol drinking, among the seventeen factors, was the most important risk factor to develop MPT in upper aerodigestive tract (OR: 7.071, 95% C.I.: 2.134–23.434). For those with high score in polygenic model, routine screening of upper digestive tract including laryngoscope and esophagoscope is suggested to detect new primaries early.
KW - Head and neck cancer
KW - Multiple primary cancer
KW - Single nucleotide polymorphism
KW - SNP array
KW - Upper aerodigestive tract
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U2 - 10.3390/jpm11050425
DO - 10.3390/jpm11050425
M3 - Article
AN - SCOPUS:85106968582
SN - 2075-4426
VL - 11
JO - Journal of Personalized Medicine
JF - Journal of Personalized Medicine
IS - 5
M1 - 425
ER -
