Polycaprolactone in Bone Tissue Engineering: A Comprehensive Review of Innovations in Scaffold Fabrication and Surface Modifications

Hsin Yu Liang; Wei Keung Lee; Jui Tsen Hsu; Jie Yu Shih; Tien Li Ma; Thi Thuy Tien Vo; Chiang Wen Lee; Ming Te Cheng; I. Ta Lee

doi:10.3390/jfb15090243

Polycaprolactone in Bone Tissue Engineering: A Comprehensive Review of Innovations in Scaffold Fabrication and Surface Modifications

Hsin Yu Liang, Wei Keung Lee, Jui Tsen Hsu, Jie Yu Shih, Tien Li Ma, Thi Thuy Tien Vo, Chiang Wen Lee, Ming Te Cheng, I. Ta Lee

Research output: Contribution to journal › Review article › peer-review

Abstract

Bone tissue engineering has seen significant advancements with innovative scaffold fabrication techniques such as 3D printing. This review focuses on enhancing polycaprolactone (PCL) scaffold properties through structural modifications, including surface treatments, pore architecture adjustments, and the incorporation of biomaterials like hydroxyapatite (HA). These modifications aim to improve scaffold conformation, cellular behavior, and mechanical performance, with particular emphasis on the role of mesenchymal stem cells (MSCs) in bone regeneration. The review also explores the potential of integrating nanomaterials and graphene oxide (GO) to further enhance the mechanical and biological properties of PCL scaffolds. Future directions involve optimizing scaffold structures and compositions for improved bone tissue regeneration outcomes.

Original language	English
Article number	243
Journal	Journal of Functional Biomaterials
Volume	15
Issue number	9
DOIs	https://doi.org/10.3390/jfb15090243
Publication status	Published - Sept 2024

Keywords

3D printing
bone tissue engineering
graphene oxide
hydroxyapatite
nanomaterials
polycaprolactone
scaffold modification
surface coatings

ASJC Scopus subject areas

Biomaterials
Biomedical Engineering

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10.3390/jfb15090243

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title = "Polycaprolactone in Bone Tissue Engineering: A Comprehensive Review of Innovations in Scaffold Fabrication and Surface Modifications",

abstract = "Bone tissue engineering has seen significant advancements with innovative scaffold fabrication techniques such as 3D printing. This review focuses on enhancing polycaprolactone (PCL) scaffold properties through structural modifications, including surface treatments, pore architecture adjustments, and the incorporation of biomaterials like hydroxyapatite (HA). These modifications aim to improve scaffold conformation, cellular behavior, and mechanical performance, with particular emphasis on the role of mesenchymal stem cells (MSCs) in bone regeneration. The review also explores the potential of integrating nanomaterials and graphene oxide (GO) to further enhance the mechanical and biological properties of PCL scaffolds. Future directions involve optimizing scaffold structures and compositions for improved bone tissue regeneration outcomes.",

keywords = "3D printing, bone tissue engineering, graphene oxide, hydroxyapatite, nanomaterials, polycaprolactone, scaffold modification, surface coatings",

author = "Liang, {Hsin Yu} and Lee, {Wei Keung} and Hsu, {Jui Tsen} and Shih, {Jie Yu} and Ma, {Tien Li} and Vo, {Thi Thuy Tien} and Lee, {Chiang Wen} and Cheng, {Ming Te} and Lee, {I. Ta}",

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year = "2024",

month = sep,

doi = "10.3390/jfb15090243",

language = "English",

volume = "15",

journal = "Journal of Functional Biomaterials",

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AU - Hsu, Jui Tsen

AU - Shih, Jie Yu

AU - Ma, Tien Li

AU - Vo, Thi Thuy Tien

AU - Lee, Chiang Wen

AU - Cheng, Ming Te

AU - Lee, I. Ta

PY - 2024/9

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N2 - Bone tissue engineering has seen significant advancements with innovative scaffold fabrication techniques such as 3D printing. This review focuses on enhancing polycaprolactone (PCL) scaffold properties through structural modifications, including surface treatments, pore architecture adjustments, and the incorporation of biomaterials like hydroxyapatite (HA). These modifications aim to improve scaffold conformation, cellular behavior, and mechanical performance, with particular emphasis on the role of mesenchymal stem cells (MSCs) in bone regeneration. The review also explores the potential of integrating nanomaterials and graphene oxide (GO) to further enhance the mechanical and biological properties of PCL scaffolds. Future directions involve optimizing scaffold structures and compositions for improved bone tissue regeneration outcomes.

AB - Bone tissue engineering has seen significant advancements with innovative scaffold fabrication techniques such as 3D printing. This review focuses on enhancing polycaprolactone (PCL) scaffold properties through structural modifications, including surface treatments, pore architecture adjustments, and the incorporation of biomaterials like hydroxyapatite (HA). These modifications aim to improve scaffold conformation, cellular behavior, and mechanical performance, with particular emphasis on the role of mesenchymal stem cells (MSCs) in bone regeneration. The review also explores the potential of integrating nanomaterials and graphene oxide (GO) to further enhance the mechanical and biological properties of PCL scaffolds. Future directions involve optimizing scaffold structures and compositions for improved bone tissue regeneration outcomes.

KW - 3D printing

KW - bone tissue engineering

KW - graphene oxide

KW - hydroxyapatite

KW - nanomaterials

KW - polycaprolactone

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KW - surface coatings

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Polycaprolactone in Bone Tissue Engineering: A Comprehensive Review of Innovations in Scaffold Fabrication and Surface Modifications

Abstract

Keywords

ASJC Scopus subject areas

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