The genotoxic potential of podophyllin (PD) was investigated in this study. PD increased bacterial revertants and abnormal chromosomal structures in a concentration-dependent manner, both with and without metabolic activating enzymes, and increased the incidence of micronuclei in imprinted control region mouse reticulocytes. Results from three studied constituents of PD, such as podophyllotoxin, kampferol, and quercetin, suggested that the mutagenic effect of PD was not due to the presence of podophyllotoxin, kampferol, and quercetin and might be related to other components and the formation of reactive oxygen species. The detailed mutagenic mechanisms need further investigation, and the medicinal use of PD needs to be cautioned against.

Original languageEnglish
Pages (from-to)68-76
Number of pages9
JournalDrug and Chemical Toxicology
Issue number1
Publication statusPublished - 2009


  • Ames test
  • Chromosome aberration
  • Genotoxicity
  • Micronucleus
  • Podophyllin
  • Reactive oxygen Species
  • Reactive oxygen species

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis
  • Toxicology
  • Chemical Health and Safety
  • Pharmacology


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