Abstract
Background/Aim: Oral squamous cell carcinoma (OSCC), a major malignancy in Taiwan, is an invasive epithelial neoplasm resulting in a low survival rate. Current treatments do not prevent OSCC progression, and antitumor therapies should be improved. Plumbagin, a natural compound extracted from Plumbago zeylanica L., appears to have antitumor effects in various tumors. The antitumor mechanism of plumbagin in OSCC is still unclear. This study investigated the molecular mechanism through which plumbagin induces apoptosis. Materials and Methods: To investigate the antiproliferative and pro-apoptotic effects of Plumbagin on OSCC cells and explore its underlying mechanism, cell counting kit-8, cell cycle analysis, and annexin V/PI assay were conducted. The functions of plumbagin on endoplasmic reticulum (ER) stress, reactive oxygen species (ROS).
Original language | English |
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Pages (from-to) | 1173-1182 |
Number of pages | 10 |
Journal | Anticancer Research |
Volume | 44 |
Issue number | 3 |
DOIs | |
Publication status | Published - Mar 2024 |
Keywords
- apoptosis
- ER stress
- Oral squamous cell carcinoma
- plumbagin
- ROS
ASJC Scopus subject areas
- Oncology
- Cancer Research