Plumbagin Induces Reactive Oxygen Species and Endoplasmic Reticulum Stress-related Cell Apoptosis in Human Oral Squamous Cell Carcinoma

Po Han Chen, Hsein Kun Lu, Ting Yi Renn, Tsung Ming Chang, Chia Jung Lee, Ya Ting Tsao, Po Kai Chuang, Ju Fang Liu

Research output: Contribution to journalArticlepeer-review

Abstract

Background/Aim: Oral squamous cell carcinoma (OSCC), a major malignancy in Taiwan, is an invasive epithelial neoplasm resulting in a low survival rate. Current treatments do not prevent OSCC progression, and antitumor therapies should be improved. Plumbagin, a natural compound extracted from Plumbago zeylanica L., appears to have antitumor effects in various tumors. The antitumor mechanism of plumbagin in OSCC is still unclear. This study investigated the molecular mechanism through which plumbagin induces apoptosis. Materials and Methods: To investigate the antiproliferative and pro-apoptotic effects of Plumbagin on OSCC cells and explore its underlying mechanism, cell counting kit-8, cell cycle analysis, and annexin V/PI assay were conducted. The functions of plumbagin on endoplasmic reticulum (ER) stress, reactive oxygen species (ROS).

Original languageEnglish
Pages (from-to)1173-1182
Number of pages10
JournalAnticancer Research
Volume44
Issue number3
DOIs
Publication statusPublished - Mar 2024

Keywords

  • apoptosis
  • ER stress
  • Oral squamous cell carcinoma
  • plumbagin
  • ROS

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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