Pleomorphic Hyalinizing Angiectatic Tumor of Soft Parts

Hui Chin Peng, Ming Te Huang, Da Jeng Chen, Ting-Kai Leung, Jan Show Chu

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18 Citations (Scopus)


Pleomorphic hyalinizing angiectatic tumor (PHAT) of soft parts is a rare, nonmetastasizing tumor of uncertain lineage which was first reported in 1996. Here, we report a case of PHAT and review the literature. A 49-year-old man presented with a soft and progressively enlarging mass over the right buttock for several years. On suspicion that the mass was a right gluteal lipoma, he underwent surgical excision. The excised lesion measured 14 × 6 × 3.5 cm. It had a variegated appearance with a white-tan to yellowish color on the cut surface. Some punctate hemorrhage and vessel thrombosis were seen. Microscopically, the tumor was a PHAT characterized by clusters of ectatic, fibrin-lined, thin-walled vessels, which were surrounded by a mitotically inert, spindled, pleomorphic, neoplastic stroma that contained a variable inflammatory component. Immunohistochemical study showed that the tumor cells were positive for CD34, and negative for S-100, HMB45 and actin. The patient experienced local recurrence 6 months later. The recurrent tumor was widely excised. No evidence of metastasis was found during the 18 months after the second operation. The recurrent lesion had a microscopic appearance that was similar to the initial lesion.

Original languageEnglish
Pages (from-to)616-620
Number of pages5
JournalJournal of the Formosan Medical Association = Taiwan yi zhi
Issue number8
Publication statusPublished - 2010


  • Pleomorphic hyalinizing angiectatic tumor
  • Soft tissue tumor

ASJC Scopus subject areas

  • Medicine(all)


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