Plectranthus amboinicus and Centella asiatica cream for the treatment of diabetic foot ulcers

Yuan-Sung Kuo, Hsiung-Fei Chien, William Lu

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)


Effects of a topical cream containing P. amboinicus (Lour.) Spreng. (Lamiaceae) and C. asiatica (L.) Urban (Umbelliferae) were evaluated and compared to effects of hydrocolloid fiber wound dressing for diabetic foot ulcers. A single-center, randomized, controlled, open-label study was conducted. Twenty-four type 1 or type 2 diabetes patients aged 20 years or older with Wagner grade 3 foot ulcers postsurgical debridement were enrolled between October 2008 and December 2009. Twelve randomly assigned patients were treated with WH-1 cream containing P. amboinicus and C. asiatica twice daily for two weeks. Another 12 patients were treated with hydrocolloid fiber dressings changed at 7 days or when clinically indicated. Wound condition and safety were assessed at days 7 and 14 and results were compared between groups. No statistically significant differences were seen in percent changes in wound size at 7- and 14-day assessments of WH-1 cream and hydrocolloid dressing groups. A slightly higher proportion of patients in the WH-1 cream group (10 of 12; 90.9) showed Wagner grade improvement compared to the hydrocolloid fiber dressing group but without statistical significance. For treating diabetic foot ulcers, P. amboinicus and C. asiatica cream is a safe alternative to hydrocolloid fiber dressing without significant difference in effectiveness. Copyright © 2012 Yuan-Sung Kuo et al.
Original languageEnglish
JournalEvidence-based Complementary and Alternative Medicine
Publication statusPublished - 2012
Externally publishedYes


  • Centella asiatica extract
  • opsite
  • plant extract
  • Plectranthus amboinicus extract
  • unclassified drug
  • adult
  • aged
  • article
  • Centella asiatica
  • clinical article
  • constipation
  • controlled study
  • cream
  • debridement
  • diabetic foot
  • dizziness
  • drug dosage form comparison
  • female
  • human
  • hydrocolloid dressing
  • hypoglycemia
  • insulin dependent diabetes mellitus
  • male
  • non insulin dependent diabetes mellitus
  • Plectranthus
  • Plectranthus amboinicus
  • priority journal
  • randomized controlled trial
  • safety
  • tinea pedis
  • visual field defect
  • wound dressing


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