@article{cf09daed4ae04065bbc58932302944e1,
title = "Plectranthus amboinicus and Centella asiatica cream for the treatment of diabetic foot ulcers",
abstract = "Effects of a topical cream containing P. amboinicus (Lour.) Spreng. (Lamiaceae) and C. asiatica (L.) Urban (Umbelliferae) were evaluated and compared to effects of hydrocolloid fiber wound dressing for diabetic foot ulcers. A single-center, randomized, controlled, open-label study was conducted. Twenty-four type 1 or type 2 diabetes patients aged 20 years or older with Wagner grade 3 foot ulcers postsurgical debridement were enrolled between October 2008 and December 2009. Twelve randomly assigned patients were treated with WH-1 cream containing P. amboinicus and C. asiatica twice daily for two weeks. Another 12 patients were treated with hydrocolloid fiber dressings changed at 7 days or when clinically indicated. Wound condition and safety were assessed at days 7 and 14 and results were compared between groups. No statistically significant differences were seen in percent changes in wound size at 7- and 14-day assessments of WH-1 cream and hydrocolloid dressing groups. A slightly higher proportion of patients in the WH-1 cream group (10 of 12; 90.9) showed Wagner grade improvement compared to the hydrocolloid fiber dressing group but without statistical significance. For treating diabetic foot ulcers, P. amboinicus and C. asiatica cream is a safe alternative to hydrocolloid fiber dressing without significant difference in effectiveness. Copyright {\textcopyright} 2012 Yuan-Sung Kuo et al.",
keywords = "Centella asiatica extract, opsite, plant extract, Plectranthus amboinicus extract, unclassified drug, adult, aged, article, Centella asiatica, clinical article, constipation, controlled study, cream, debridement, diabetic foot, dizziness, drug dosage form comparison, female, human, hydrocolloid dressing, hypoglycemia, insulin dependent diabetes mellitus, male, non insulin dependent diabetes mellitus, Plectranthus, Plectranthus amboinicus, priority journal, randomized controlled trial, safety, tinea pedis, visual field defect, wound dressing",
author = "Yuan-Sung Kuo and Hsiung-Fei Chien and William Lu",
note = "Export Date: 16 March 2016 通訊地址: Chien, H.-F.; Department of Surgery, National Taiwan University Hospital, Taipei 100, Taiwan; 電子郵件： hfchien@ntu.edu.tw 商標： AQUACEL; Opsite, Smith and Nephew, Taiwan 製造商： Smith and Nephew, Taiwan 參考文獻: Frykberg, R.G., Diabetic foot ulcers: Pathogenesis and management (2002) American Family Physician, 66 (9), pp. 1655-1662; Bader, M.S., Diabetic foot infection (2008) American Family Physician, 78 (1), pp. 71-79; Reiber, G.E., Smith, D.G., Vileikyte, L., Lavery, L.A., Boyko, E.J., Boulton, A.J.M., Del Aguila, M., Causal pathways for incident lower-extremity ulcers in patients with diabetes from two settings (1999) Diabetes Care, 22 (1), pp. 157-162. , DOI 10.2337/diacare.22.1.157; Frykberg, R.G., Wittmayer, B., Zgonis, T., Surgical Management of Diabetic Foot Infections and Osteomyelitis (2007) Clinics in Podiatric Medicine and Surgery, 24 (3), pp. 469-482. , DOI 10.1016/j.cpm.2007.04.001, PII S0891842207000316, Advances in the Treatment of the Diabetic Foot; Lipsky, B.A., Berendt, A.R., Deery, H.G., Embil, J.M., Joseph, W.S., Karchmer, A.W., LeFrock, J.L., Tan, J.S., Diagnosis and treatment of diabetic foot infections (2004) Clinical Infectious Diseases, 39 (7), pp. 885-910. , DOI 10.1086/424846; Lipsky, B.A., Armstrong, D.G., Citron, D.M., Tice, A.D., Morgenstern, D.E., Abramson, M.A., Ertapenem versus piperacillin/tazobactam for diabetic foot infections (SIDESTEP): Prospective, randomised, controlled, double-blinded, multicentre trial (2005) Lancet, 366 (9498), pp. 1695-1703. , DOI 10.1016/S0140-6736(05)67694-5, PII S0140673605676945; Lipsky, B.A., Giordano, P., Choudhri, S., Song, J., Treating diabetic foot infections with sequential intravenous to oral moxifloxacin compared with piperacillin-tazobactam/ amoxicillin-clavulanate (2007) Journal of Antimicrobial Chemotherapy, 60 (2), pp. 370-376. , DOI 10.1093/jac/dkm130; Nagoba, B.S., Gandhi, R.C., Wadher, B.J., Rao, A., Hartalkar, A.R., Selkar, S.P., A simple and effective approach for the treatment of diabetic foot ulcers with different Wagner grades (2010) International Wound Journal, 7 (3), pp. 153-158; Chen, L.C., Wang, B.R., Chou, Y.C., Tien, J.H., Drug utilization pattern of Chinese herbal medicines in a general hospital in Taiwan (2005) Pharmacoepidemiology and Drug Safety, 14 (9), pp. 651-657. , DOI 10.1002/pds.1087; Lukhoba, C.W., Simmonds, M.S.J., Paton, A.J., Plectranthus: A review of ethnobotanical uses (2006) Journal of Ethnopharmacology, 103 (1), pp. 1-24. , DOI 10.1016/j.jep.2005.09.011, PII S0378874105006215; Gurgel, A.P.A.D., Da Silva, J.G., Grangeiro, A.R.S., Oliveira, D.C., Lima, C.M.P., Da Silva, A.C.P., Oliveira, R.A.G., Souza, I.A., In vivo study of the anti-inflammatory and antitumor activities of leaves from Plectranthus amboinicus (Lour.) 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year = "2012",
doi = "10.1155/2012/418679",
language = "English",
volume = "2012",
journal = "Evidence-based Complementary and Alternative Medicine",
issn = "1741-427X",
publisher = "Hindawi Publishing Corporation",
}
