Platelet‐derived biomaterials exert chondroprotective and chondroregenerative effects on diabetes mellitus‐induced intervertebral disc degeneration

Wen Cheng Lo, Chun Chao Chang, Chun Hao Chan, Abhinay Kumar Singh, Yue Hua Deng, Chia Ying Lin, Wen Tsao, Shaw Ting Chien, Chang Hsien Lin, Win Ping Deng

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Complications of diabetes mellitus (DM) range from acute to chronic conditions, leading to multiorgan disorders such as nephropathy, retinopathy, and neuropathy. However, little is known about the influence of DM on intervertebral disc degeneration (IVDD). Moreover, traditional surgical outcomes in DM patients have been found poor, and to date, no definitive alternative treatment exists for DM‐induced IVDD. Recently, among various novel approaches in regenerative medicine, the concentrated platelet‐derived biomaterials (PDB), which is comprised of transforming growth factor‐β1 (TGF‐β1), platelet‐derived growth factor (PDGF), etc., have been reported as safe, biocompatible, and efficacious alternatives for various disorders. Therefore, we initially investigated the correlations between DM and IVDD, through establishing in vitro and in vivo DM models, and further evaluated the therapeutic effects of PDB in this comorbid pathology. In vitro model was established by culturing immortalized human nucleus pulposus cells (ihNPs) in high‐glucose medium, whereas in vivo DM model was developed by administering streptozotocin, nicotinamide and high‐fat diet to the mice. Our results revealed that DM deteriorates both ihNPs and IVD tissues, by elevating reactive oxygen species (ROS)‐induced oxidative stress, inhibiting chondrogenic markers and disc height. Contrarily, PDB ameliorated IVDD by restoring cellular growth, chondrogenic markers and disc height, possibly through suppressing ROS levels. These data imply that PDB may serve as a potential chondroprotective and chondroregenerative candidate for DM‐induced IVDD.

Original languageEnglish
Article number1054
Issue number10
Publication statusPublished - Oct 2021


  • Diabetes mellitus (DM)
  • Hyperglycemia
  • Immortalized human nucleus pulposus cells (ihNPs)
  • Intervertebral disc degeneration (IVDD)
  • Platelet‐derived biomaterials (PDB)
  • Reactive oxygen species (ROS)

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • General Biochemistry,Genetics and Molecular Biology
  • Space and Planetary Science
  • Palaeontology


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