Platelet count/spleen diameter ratio in the differentiation of alcoholic liver disease from alcoholic liver disease plus viral hepatitis (B, C or B + C) or viral hepatitis alone

Jui Ting Hu, Han Yu Chang, Chih Wen Lin, Yi Wen Huang, Sien Sing Yang

Research output: Contribution to journalArticlepeer-review

Abstract

Aim: Alcoholic liver disease and viral hepatitis are treated differently, making differential diagnosis essential. We aimed to determine whether platelet/spleen ratios can be used for differential diagnosis. Methods: This retrospective study enrolled 180 patients diagnosed with alcoholic (n=56) or viral liver disease (n=68) or combined alcoholic and viral liver disease (n=56) between 2009 and 2012. Patients without liver biopsy or complete data were excluded. Patients’ demographic and clinical data were collected, platelet/spleen ratios were determined. Data were compared between groups and associations between platelet/spleen ratios and alcoholic or viral liver disease were determined by univariate and ROC analysis. Results: Platelet/spleen ratios and liver function parameters were significantly different between groups (all P-values <0.05). Univariate analysis of platelet/spleen ratios compared between different groups revealed significant differences in platelet/spleen ratios between alcohol vs. combined group and viral vs. combined group but not between alcohol vs. viral group. Optimal cut-offs of platelet/spleen ratio to differentiate alcoholic liver disease and viral liver disease from combined alcoholic and viral liver disease were 2306 and 1650, respectively. Conclusion: Platelet/spleen ratio can only be used to differentiate alcoholic or viral liver disease from coexisting alcoholic and viral liver disease in conjunction with confirmation of viral hepatitis.

Original languageEnglish
Article numberIJCEM0020794
Pages (from-to)10764-10772
Number of pages9
JournalInternational Journal of Clinical and Experimental Medicine
Volume10
Issue number7
Publication statusPublished - Jul 30 2017

Keywords

  • Alcoholic liver disease
  • Differential diagnosis
  • Platelet count/spleen diameter ratio
  • Viral hepatitis

ASJC Scopus subject areas

  • General Biochemistry,Genetics and Molecular Biology

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