Platelet ATP, Thyroid Hormone Receptor on Integrin αvβ3 and Cancer Metastasis

Paul J. Davis; Shaker A. Mousa; Geraldine P. Schechter; Hung Yun Lin

doi:10.1007/s12672-019-00371-4

Platelet ATP, Thyroid Hormone Receptor on Integrin αvβ3 and Cancer Metastasis

Paul J. Davis, Shaker A. Mousa, Geraldine P. Schechter, Hung Yun Lin

Research output: Contribution to journal › Review article › peer-review

23 Citations (Scopus)

Abstract

Activated platelets may contribute to the metastatic behavior of tumor cells when the cancer cells and platelets interact. The interaction requires cell and platelet surface integrin. Thyroid hormone as L-thyroxine (T4) is the principal ligand for a hormone receptor on integrin αvβ3 on tumor cells and platelets. T4 activates the integrin, promoting platelet aggregation and degranulation (local ATP release) and stimulating tumor cell proliferation. By a variety of molecular mechanisms reviewed here, extracellular ATP promotes tumor cell invasiveness and metastasis and supports a role for T4 as a pro-metastatic factor.

Original language	English
Pages (from-to)	13-16
Number of pages	4
Journal	Hormones and Cancer
Volume	11
Issue number	1
DOIs	https://doi.org/10.1007/s12672-019-00371-4
Publication status	Published - Feb 1 2020

Keywords

3,5,3′-Triiodo-L-thyronine (T3)
Degranulation
Integrin
L-Thyroxine (T4)
Metastasis
Thyroid hormone receptors
Tumor cell invasiveness

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Oncology
Endocrinology
Endocrine and Autonomic Systems
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s12672-019-00371-4

Cite this

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title = "Platelet ATP, Thyroid Hormone Receptor on Integrin αvβ3 and Cancer Metastasis",

abstract = "Activated platelets may contribute to the metastatic behavior of tumor cells when the cancer cells and platelets interact. The interaction requires cell and platelet surface integrin. Thyroid hormone as L-thyroxine (T4) is the principal ligand for a hormone receptor on integrin αvβ3 on tumor cells and platelets. T4 activates the integrin, promoting platelet aggregation and degranulation (local ATP release) and stimulating tumor cell proliferation. By a variety of molecular mechanisms reviewed here, extracellular ATP promotes tumor cell invasiveness and metastasis and supports a role for T4 as a pro-metastatic factor.",

keywords = "3,5,3′-Triiodo-L-thyronine (T3), Degranulation, Integrin, L-Thyroxine (T4), Metastasis, Thyroid hormone receptors, Tumor cell invasiveness",

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AU - Davis, Paul J.

AU - Mousa, Shaker A.

AU - Schechter, Geraldine P.

AU - Lin, Hung Yun

PY - 2020/2/1

Y1 - 2020/2/1

N2 - Activated platelets may contribute to the metastatic behavior of tumor cells when the cancer cells and platelets interact. The interaction requires cell and platelet surface integrin. Thyroid hormone as L-thyroxine (T4) is the principal ligand for a hormone receptor on integrin αvβ3 on tumor cells and platelets. T4 activates the integrin, promoting platelet aggregation and degranulation (local ATP release) and stimulating tumor cell proliferation. By a variety of molecular mechanisms reviewed here, extracellular ATP promotes tumor cell invasiveness and metastasis and supports a role for T4 as a pro-metastatic factor.

AB - Activated platelets may contribute to the metastatic behavior of tumor cells when the cancer cells and platelets interact. The interaction requires cell and platelet surface integrin. Thyroid hormone as L-thyroxine (T4) is the principal ligand for a hormone receptor on integrin αvβ3 on tumor cells and platelets. T4 activates the integrin, promoting platelet aggregation and degranulation (local ATP release) and stimulating tumor cell proliferation. By a variety of molecular mechanisms reviewed here, extracellular ATP promotes tumor cell invasiveness and metastasis and supports a role for T4 as a pro-metastatic factor.

KW - 3,5,3′-Triiodo-L-thyronine (T3)

KW - Degranulation

KW - Integrin

KW - L-Thyroxine (T4)

KW - Metastasis

KW - Thyroid hormone receptors

KW - Tumor cell invasiveness

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U2 - 10.1007/s12672-019-00371-4

DO - 10.1007/s12672-019-00371-4

M3 - Review article

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SN - 1868-8497

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Platelet ATP, Thyroid Hormone Receptor on Integrin αvβ3 and Cancer Metastasis

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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