Plasma interleukin-18 levels in hemodialysis patients: Increased by dialysis process and association with interleukin-6 and tumor necrotic factor-α

Chih Kang Chiang; Jen Wen Huang; Shih Ping Hsu; Tai I. Ho; Mei Fen Pai; Yu Sen Peng; Shing Hwa Liu; Kuan Yu Hung; Tun Jun Tsai

doi:10.1159/000090411

Plasma interleukin-18 levels in hemodialysis patients: Increased by dialysis process and association with interleukin-6 and tumor necrotic factor-α

Chih Kang Chiang, Jen Wen Huang, Shih Ping Hsu, Tai I. Ho, Mei Fen Pai, Yu Sen Peng, Shing Hwa Liu, Kuan Yu Hung, Tun Jun Tsai

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Background/Aims: This study investigated changes of interleukin-18 (IL-18) levels before and after dialysis, and the possible association with other pro-inflammatory cytokines, such as interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α). Methods: Plasma IL-18 of healthy controls, and pre- and post-dialysis of uremic patients undergoing hemodialysis (HD) were evaluated by ELISA methodology. Results: Plasma IL-18 levels were significantly increased in patients with maintenance HD (p < 0.001) compared to its level in normal subjects. When compared to pre-dialysis levels, a significant increase in plasma IL-18 was measured at the end of HD (p = 0.032). There was a significant correlation among plasma IL-18, IL-6 and TNF-α levels in HD patients. Conclusion: Plasma IL-18 concentration was significantly higher in HD patients and was significantly elevated by cellulose-based HD processes. Pre-activation of immunologically active cells may contribute to the association between pre-dialysis IL-18 and post-dialysis IL-6 and TNF-α levels.

Original language	English
Pages (from-to)	174-179
Number of pages	6
Journal	Blood Purification
Volume	24
Issue number	2
DOIs	https://doi.org/10.1159/000090411
Publication status	Published - Feb 2006
Externally published	Yes

Keywords

Hemodialysis process
Interleukin-18
Interleukin-6
Pre-activation
Tumor necrosis factor-α

ASJC Scopus subject areas

Hematology
Nephrology

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10.1159/000090411

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@article{8e396e50b6eb4287af6b254f9744b780,

title = "Plasma interleukin-18 levels in hemodialysis patients: Increased by dialysis process and association with interleukin-6 and tumor necrotic factor-α",

abstract = "Background/Aims: This study investigated changes of interleukin-18 (IL-18) levels before and after dialysis, and the possible association with other pro-inflammatory cytokines, such as interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α). Methods: Plasma IL-18 of healthy controls, and pre- and post-dialysis of uremic patients undergoing hemodialysis (HD) were evaluated by ELISA methodology. Results: Plasma IL-18 levels were significantly increased in patients with maintenance HD (p < 0.001) compared to its level in normal subjects. When compared to pre-dialysis levels, a significant increase in plasma IL-18 was measured at the end of HD (p = 0.032). There was a significant correlation among plasma IL-18, IL-6 and TNF-α levels in HD patients. Conclusion: Plasma IL-18 concentration was significantly higher in HD patients and was significantly elevated by cellulose-based HD processes. Pre-activation of immunologically active cells may contribute to the association between pre-dialysis IL-18 and post-dialysis IL-6 and TNF-α levels.",

keywords = "Hemodialysis process, Interleukin-18, Interleukin-6, Pre-activation, Tumor necrosis factor-α",

author = "Chiang, {Chih Kang} and Huang, {Jen Wen} and Hsu, {Shih Ping} and Ho, {Tai I.} and Pai, {Mei Fen} and Peng, {Yu Sen} and Liu, {Shing Hwa} and Hung, {Kuan Yu} and Tsai, {Tun Jun}",

year = "2006",

month = feb,

doi = "10.1159/000090411",

language = "English",

volume = "24",

pages = "174--179",

journal = "Blood Purification",

issn = "0253-5068",

publisher = "S. Karger AG",

number = "2",

}

TY - JOUR

T1 - Plasma interleukin-18 levels in hemodialysis patients

T2 - Increased by dialysis process and association with interleukin-6 and tumor necrotic factor-α

AU - Chiang, Chih Kang

AU - Huang, Jen Wen

AU - Hsu, Shih Ping

AU - Ho, Tai I.

AU - Pai, Mei Fen

AU - Peng, Yu Sen

AU - Liu, Shing Hwa

AU - Hung, Kuan Yu

AU - Tsai, Tun Jun

PY - 2006/2

Y1 - 2006/2

N2 - Background/Aims: This study investigated changes of interleukin-18 (IL-18) levels before and after dialysis, and the possible association with other pro-inflammatory cytokines, such as interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α). Methods: Plasma IL-18 of healthy controls, and pre- and post-dialysis of uremic patients undergoing hemodialysis (HD) were evaluated by ELISA methodology. Results: Plasma IL-18 levels were significantly increased in patients with maintenance HD (p < 0.001) compared to its level in normal subjects. When compared to pre-dialysis levels, a significant increase in plasma IL-18 was measured at the end of HD (p = 0.032). There was a significant correlation among plasma IL-18, IL-6 and TNF-α levels in HD patients. Conclusion: Plasma IL-18 concentration was significantly higher in HD patients and was significantly elevated by cellulose-based HD processes. Pre-activation of immunologically active cells may contribute to the association between pre-dialysis IL-18 and post-dialysis IL-6 and TNF-α levels.

AB - Background/Aims: This study investigated changes of interleukin-18 (IL-18) levels before and after dialysis, and the possible association with other pro-inflammatory cytokines, such as interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α). Methods: Plasma IL-18 of healthy controls, and pre- and post-dialysis of uremic patients undergoing hemodialysis (HD) were evaluated by ELISA methodology. Results: Plasma IL-18 levels were significantly increased in patients with maintenance HD (p < 0.001) compared to its level in normal subjects. When compared to pre-dialysis levels, a significant increase in plasma IL-18 was measured at the end of HD (p = 0.032). There was a significant correlation among plasma IL-18, IL-6 and TNF-α levels in HD patients. Conclusion: Plasma IL-18 concentration was significantly higher in HD patients and was significantly elevated by cellulose-based HD processes. Pre-activation of immunologically active cells may contribute to the association between pre-dialysis IL-18 and post-dialysis IL-6 and TNF-α levels.

KW - Hemodialysis process

KW - Interleukin-18

KW - Interleukin-6

KW - Pre-activation

KW - Tumor necrosis factor-α

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M3 - Article

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JO - Blood Purification

JF - Blood Purification

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ER -

Plasma interleukin-18 levels in hemodialysis patients: Increased by dialysis process and association with interleukin-6 and tumor necrotic factor-α

Abstract

Keywords

ASJC Scopus subject areas

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