Plasma interleukin-18 levels in chronic renal failure and continuous ambulatory peritoneal dialysis

Chih Kang Chiang; Shih Ping Hsu; Mei Fen Pai; Yu Sen Peng; Tai I. Ho; Shing Hwa Liu; Kuan Yu Hung; Tun Jun Tsai; Bor Shen Hsieh

doi:10.1159/000083620

Plasma interleukin-18 levels in chronic renal failure and continuous ambulatory peritoneal dialysis

Chih Kang Chiang, Shih Ping Hsu, Mei Fen Pai, Yu Sen Peng, Tai I. Ho, Shing Hwa Liu, Kuan Yu Hung, Tun Jun Tsai, Bor Shen Hsieh

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

Background/Aims: Based on associations of interleukin (IL)-18 with chronic inflammation, we investigated IL-18, IL-6, and tumor necrosis factor-α (TNF-α) in patients with chronic renal failure (CRF) and patients undergoing continuous ambulatory peritoneal dialysis (CAPD). Methods: Plasma was evaluated by ELISA methodology in 15 healthy controls, 27 CRF and 15 CAPD patients. Results: Plasma IL-18 levels in CRF (572.5 ± 41.9 pg/ml) or CAPD (479.2 ± 47.4 pg/ml) were significantly higher than normal (263.6 ± 20.0 pg/ml), but there was no difference in IL-18 between CRF and CAPD patients. The IL-18 concentration negatively correlated with creatinine clearance (Ccr). However, the duration of dialysis, normalized protein nitrogen appearance, weekly Ccr, and K_t/V_urea were not correlated with plasma IL-18 in CAPD. The plasma IL-18 concentration was positively correlated with TNF-α but not with IL-6 in renal failure patients with or without CAPD. Conclusion: Uremia is the principal origin of increased plasma IL-18 in these patients. Increased IL-18 levels may be associated with Th1 differentiation and elevated TNF-α.

Original language	English
Pages (from-to)	144-148
Number of pages	5
Journal	Blood Purification
Volume	23
Issue number	2
DOIs	https://doi.org/10.1159/000083620
Publication status	Published - 2005
Externally published	Yes

Keywords

Chronic renal failure
Continuous ambulatory peritoneal dialysis
Interleukin-18
Interleukin-6
Tumor necrosis factor-α

ASJC Scopus subject areas

Hematology
Nephrology

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10.1159/000083620

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title = "Plasma interleukin-18 levels in chronic renal failure and continuous ambulatory peritoneal dialysis",

abstract = "Background/Aims: Based on associations of interleukin (IL)-18 with chronic inflammation, we investigated IL-18, IL-6, and tumor necrosis factor-α (TNF-α) in patients with chronic renal failure (CRF) and patients undergoing continuous ambulatory peritoneal dialysis (CAPD). Methods: Plasma was evaluated by ELISA methodology in 15 healthy controls, 27 CRF and 15 CAPD patients. Results: Plasma IL-18 levels in CRF (572.5 ± 41.9 pg/ml) or CAPD (479.2 ± 47.4 pg/ml) were significantly higher than normal (263.6 ± 20.0 pg/ml), but there was no difference in IL-18 between CRF and CAPD patients. The IL-18 concentration negatively correlated with creatinine clearance (Ccr). However, the duration of dialysis, normalized protein nitrogen appearance, weekly Ccr, and Kt/Vurea were not correlated with plasma IL-18 in CAPD. The plasma IL-18 concentration was positively correlated with TNF-α but not with IL-6 in renal failure patients with or without CAPD. Conclusion: Uremia is the principal origin of increased plasma IL-18 in these patients. Increased IL-18 levels may be associated with Th1 differentiation and elevated TNF-α.",

keywords = "Chronic renal failure, Continuous ambulatory peritoneal dialysis, Interleukin-18, Interleukin-6, Tumor necrosis factor-α",

author = "Chiang, {Chih Kang} and Hsu, {Shih Ping} and Pai, {Mei Fen} and Peng, {Yu Sen} and Ho, {Tai I.} and Liu, {Shing Hwa} and Hung, {Kuan Yu} and Tsai, {Tun Jun} and Hsieh, {Bor Shen}",

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doi = "10.1159/000083620",

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journal = "Blood Purification",

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T1 - Plasma interleukin-18 levels in chronic renal failure and continuous ambulatory peritoneal dialysis

AU - Chiang, Chih Kang

AU - Hsu, Shih Ping

AU - Pai, Mei Fen

AU - Peng, Yu Sen

AU - Ho, Tai I.

AU - Liu, Shing Hwa

AU - Hung, Kuan Yu

AU - Tsai, Tun Jun

AU - Hsieh, Bor Shen

PY - 2005

Y1 - 2005

N2 - Background/Aims: Based on associations of interleukin (IL)-18 with chronic inflammation, we investigated IL-18, IL-6, and tumor necrosis factor-α (TNF-α) in patients with chronic renal failure (CRF) and patients undergoing continuous ambulatory peritoneal dialysis (CAPD). Methods: Plasma was evaluated by ELISA methodology in 15 healthy controls, 27 CRF and 15 CAPD patients. Results: Plasma IL-18 levels in CRF (572.5 ± 41.9 pg/ml) or CAPD (479.2 ± 47.4 pg/ml) were significantly higher than normal (263.6 ± 20.0 pg/ml), but there was no difference in IL-18 between CRF and CAPD patients. The IL-18 concentration negatively correlated with creatinine clearance (Ccr). However, the duration of dialysis, normalized protein nitrogen appearance, weekly Ccr, and Kt/Vurea were not correlated with plasma IL-18 in CAPD. The plasma IL-18 concentration was positively correlated with TNF-α but not with IL-6 in renal failure patients with or without CAPD. Conclusion: Uremia is the principal origin of increased plasma IL-18 in these patients. Increased IL-18 levels may be associated with Th1 differentiation and elevated TNF-α.

AB - Background/Aims: Based on associations of interleukin (IL)-18 with chronic inflammation, we investigated IL-18, IL-6, and tumor necrosis factor-α (TNF-α) in patients with chronic renal failure (CRF) and patients undergoing continuous ambulatory peritoneal dialysis (CAPD). Methods: Plasma was evaluated by ELISA methodology in 15 healthy controls, 27 CRF and 15 CAPD patients. Results: Plasma IL-18 levels in CRF (572.5 ± 41.9 pg/ml) or CAPD (479.2 ± 47.4 pg/ml) were significantly higher than normal (263.6 ± 20.0 pg/ml), but there was no difference in IL-18 between CRF and CAPD patients. The IL-18 concentration negatively correlated with creatinine clearance (Ccr). However, the duration of dialysis, normalized protein nitrogen appearance, weekly Ccr, and Kt/Vurea were not correlated with plasma IL-18 in CAPD. The plasma IL-18 concentration was positively correlated with TNF-α but not with IL-6 in renal failure patients with or without CAPD. Conclusion: Uremia is the principal origin of increased plasma IL-18 in these patients. Increased IL-18 levels may be associated with Th1 differentiation and elevated TNF-α.

KW - Chronic renal failure

KW - Continuous ambulatory peritoneal dialysis

KW - Interleukin-18

KW - Interleukin-6

KW - Tumor necrosis factor-α

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Plasma interleukin-18 levels in chronic renal failure and continuous ambulatory peritoneal dialysis

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