Plasma folate level, urinary arsenic methylation profiles, and urothelial carcinoma susceptibility

Yung Kai Huang; Yeong Shiau Pu; Chi Jung Chung; Horng Sheng Shiue; Mo Hsiung Yang; Chien Jen Chen; Yu Mei Hsueh

doi:10.1016/j.fct.2007.10.017

Plasma folate level, urinary arsenic methylation profiles, and urothelial carcinoma susceptibility

Yung Kai Huang, Yeong Shiau Pu, Chi Jung Chung, Horng Sheng Shiue, Mo Hsiung Yang, Chien Jen Chen, Yu Mei Hsueh

Research output: Contribution to journal › Article › peer-review

54 Citations (Scopus)

Abstract

To elucidate the influence of folate concentration on the association between urinary arsenic profiles and urothelial carcinoma (UC) risks in subjects without evident arsenic exposure, 177 UC cases and 488 controls were recruited between September 2002 and May 2004. Urinary arsenic species including inorganic arsenic, monomethylarsonic acid (MMA^V) and dimethylarsinic acid (DMA^V) were determined by employing a high performance liquid chromatography-linked hydride generator and atomic absorption spectrometry procedure. After adjustment for suspected risk factors of UC, the higher indicators of urinary total arsenic levels, percentage of inorganic arsenic, percentage of MMA^V, and primary methylation index were associated with increased risk of UC. On the other hand, the higher plasma folate levels, urinary percentage of DMA^V and secondary methylation index were associated with decreased risk of UC. A dose-response relationship was shown between plasma folate levels or methylation indices of arsenic species and UC risk in the respective quartile strata. The plasma folate was found to interact with urinary arsenic profiles in affecting the UC risk. The results of this study may identify the susceptible subpopulations and provide insight into the carcinogenic mechanisms of arsenic even at low arsenic exposure.

Original language	English
Pages (from-to)	929-938
Number of pages	10
Journal	Food and Chemical Toxicology
Volume	46
Issue number	3
DOIs	https://doi.org/10.1016/j.fct.2007.10.017
Publication status	Published - Mar 2008

Keywords

Interaction
Plasma folate level
Urinary arsenic species
Urothelial carcinoma

ASJC Scopus subject areas

Food Science
Toxicology

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10.1016/j.fct.2007.10.017

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@article{5f58a0a694fb4a2f94160200c47595a2,

title = "Plasma folate level, urinary arsenic methylation profiles, and urothelial carcinoma susceptibility",

abstract = "To elucidate the influence of folate concentration on the association between urinary arsenic profiles and urothelial carcinoma (UC) risks in subjects without evident arsenic exposure, 177 UC cases and 488 controls were recruited between September 2002 and May 2004. Urinary arsenic species including inorganic arsenic, monomethylarsonic acid (MMAV) and dimethylarsinic acid (DMAV) were determined by employing a high performance liquid chromatography-linked hydride generator and atomic absorption spectrometry procedure. After adjustment for suspected risk factors of UC, the higher indicators of urinary total arsenic levels, percentage of inorganic arsenic, percentage of MMAV, and primary methylation index were associated with increased risk of UC. On the other hand, the higher plasma folate levels, urinary percentage of DMAV and secondary methylation index were associated with decreased risk of UC. A dose-response relationship was shown between plasma folate levels or methylation indices of arsenic species and UC risk in the respective quartile strata. The plasma folate was found to interact with urinary arsenic profiles in affecting the UC risk. The results of this study may identify the susceptible subpopulations and provide insight into the carcinogenic mechanisms of arsenic even at low arsenic exposure.",

keywords = "Interaction, Plasma folate level, Urinary arsenic species, Urothelial carcinoma",

author = "Huang, {Yung Kai} and Pu, {Yeong Shiau} and Chung, {Chi Jung} and Shiue, {Horng Sheng} and Yang, {Mo Hsiung} and Chen, {Chien Jen} and Hsueh, {Yu Mei}",

note = "Funding Information: This study was supported by Grants NSC91-3112-B-038-0019, NSC92-3112-B-038-001, NSC93-3112-B-038-001, NSC94-2314-B-038-023, NSC95-2314-B-038-007, and NSC-96-2314-B-002-311 from the National Science Council, Executive Yuan, ROC. We thank Dr. Ying-Chin Lin of the Health Management Center, Taipei Medical University Municipal Wan Fang Hospital for recruitment of the healthy controls. Copyright: Copyright 2008 Elsevier B.V., All rights reserved.",

year = "2008",

month = mar,

doi = "10.1016/j.fct.2007.10.017",

language = "English",

volume = "46",

pages = "929--938",

journal = "Food and Chemical Toxicology",

issn = "0278-6915",

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TY - JOUR

T1 - Plasma folate level, urinary arsenic methylation profiles, and urothelial carcinoma susceptibility

AU - Huang, Yung Kai

AU - Pu, Yeong Shiau

AU - Chung, Chi Jung

AU - Shiue, Horng Sheng

AU - Yang, Mo Hsiung

AU - Chen, Chien Jen

AU - Hsueh, Yu Mei

N1 - Funding Information: This study was supported by Grants NSC91-3112-B-038-0019, NSC92-3112-B-038-001, NSC93-3112-B-038-001, NSC94-2314-B-038-023, NSC95-2314-B-038-007, and NSC-96-2314-B-002-311 from the National Science Council, Executive Yuan, ROC. We thank Dr. Ying-Chin Lin of the Health Management Center, Taipei Medical University Municipal Wan Fang Hospital for recruitment of the healthy controls. Copyright: Copyright 2008 Elsevier B.V., All rights reserved.

PY - 2008/3

Y1 - 2008/3

N2 - To elucidate the influence of folate concentration on the association between urinary arsenic profiles and urothelial carcinoma (UC) risks in subjects without evident arsenic exposure, 177 UC cases and 488 controls were recruited between September 2002 and May 2004. Urinary arsenic species including inorganic arsenic, monomethylarsonic acid (MMAV) and dimethylarsinic acid (DMAV) were determined by employing a high performance liquid chromatography-linked hydride generator and atomic absorption spectrometry procedure. After adjustment for suspected risk factors of UC, the higher indicators of urinary total arsenic levels, percentage of inorganic arsenic, percentage of MMAV, and primary methylation index were associated with increased risk of UC. On the other hand, the higher plasma folate levels, urinary percentage of DMAV and secondary methylation index were associated with decreased risk of UC. A dose-response relationship was shown between plasma folate levels or methylation indices of arsenic species and UC risk in the respective quartile strata. The plasma folate was found to interact with urinary arsenic profiles in affecting the UC risk. The results of this study may identify the susceptible subpopulations and provide insight into the carcinogenic mechanisms of arsenic even at low arsenic exposure.

AB - To elucidate the influence of folate concentration on the association between urinary arsenic profiles and urothelial carcinoma (UC) risks in subjects without evident arsenic exposure, 177 UC cases and 488 controls were recruited between September 2002 and May 2004. Urinary arsenic species including inorganic arsenic, monomethylarsonic acid (MMAV) and dimethylarsinic acid (DMAV) were determined by employing a high performance liquid chromatography-linked hydride generator and atomic absorption spectrometry procedure. After adjustment for suspected risk factors of UC, the higher indicators of urinary total arsenic levels, percentage of inorganic arsenic, percentage of MMAV, and primary methylation index were associated with increased risk of UC. On the other hand, the higher plasma folate levels, urinary percentage of DMAV and secondary methylation index were associated with decreased risk of UC. A dose-response relationship was shown between plasma folate levels or methylation indices of arsenic species and UC risk in the respective quartile strata. The plasma folate was found to interact with urinary arsenic profiles in affecting the UC risk. The results of this study may identify the susceptible subpopulations and provide insight into the carcinogenic mechanisms of arsenic even at low arsenic exposure.

KW - Interaction

KW - Plasma folate level

KW - Urinary arsenic species

KW - Urothelial carcinoma

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Plasma folate level, urinary arsenic methylation profiles, and urothelial carcinoma susceptibility

Abstract

Keywords

ASJC Scopus subject areas

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