Pivotal role of curcuminoids on the antimutagenic activity of Curcuma zedoaria extracts

Chiung Huei Peng, Wen Ta Chiu, Chi Wen Juan, Jeng Leun Mau, Chien Chou Chen, Chiung Chi Peng, Eric Yc Lai, Charng Cherng Chyau

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)


In an investigation of the mutagenic activity of two extracts from rhizomes of Curcuma zedoaria (the mathanolic, CME, and the aqueous, CAE) and antimutagenic activity against mutagens, either 2-amino-3-methylimidazo (4,5-f) quinoline (IQ) or 4-nitroquinoline-N-oxide (4-NQO), in dosages of 150 μg/plate was assayed by using Salmonella typhimurium TA97, TA98, TA100, and TA102 strains. We found that the two extracts showed no mutagenicity when tested with all the tester strains either with or without the S9 mix. Moreover, the two extracts, particularly CME, presented a greater antimutagenicity than CAE did either in IQ or 4-NQO mutagens. However, the inhibition effect on lipid peroxidation was similar with both extracts. The amount of major antioxidants β-carotene, ascorbic acid, and total polyphenols present in both CME and CAE were similar between each other. In contrast, the content of cucuminoids (44.3mg/g extract) in CME were only found in small amounts in CAE (0.09mg/g extract). Consequently, although both of the extracts showed similar antioxidant effects, the curcuminoids, which seem to be the main active principles from this plant, were suggested to play a pivotal role in antimutagenic activity.

Original languageEnglish
Pages (from-to)64-76
Number of pages13
JournalDrug and Chemical Toxicology
Issue number1
Publication statusPublished - Jan 2010


  • Ames test
  • Antimutagenic activity
  • Antioxidant effect
  • Curcuma zedoaria
  • Curcuminoids
  • Internucleosomal DNA

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology
  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis
  • Chemical Health and Safety


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