@article{7d5961d3d398457a9db20c7f102b8750,
title = "Pilot study of focused ultrasound for drug-resistant epilepsy",
abstract = "Objective: The neuromodulatory effects of focused ultrasound (FUS) have been demonstrated in animal epilepsy models; however, the safety and efficacy of FUS in humans with epilepsy have not been well established. Patients with drug-resistant epilepsy (DRE) undergoing stereo-electroencephalography (SEEG) provide an opportunity to investigate the neuromodulatory effects of FUS in humans. Methods: Patients with DRE undergoing SEEG for localization of the seizure onset zone (SOZ) were prospectively enrolled. FUS was delivered to the SOZ using a neuronavigation-guided FUS system (ceiling spatial-peak temporal-average intensity level = 2.8 W/cm2, duty cycle = 30%, modulating duration = 10 min). Simultaneous SEEG recordings were obtained during sonication and for 3 days after treatment. Seizures, interictal epileptiform discharges, and adverse events after FUS were monitored. Results: Six patients met the eligibility criteria and completed FUS treatment. A decrease in seizure frequency was observed in two patients within the 3-day follow-up; however, one patient presented an increase in the frequency of subclinical seizures. Posttreatment magnetic resonance imaging revealed neither lesion nor brain edema. Significant changes in spectral power of SEEG were noted at the targeted electrodes during FUS treatment. One patient reported subjective scalp heating during FUS, and one patient developed transient naming and memory impairment that resolved within 3 weeks after FUS. Significance: FUS can be safely delivered to the SOZ of patients with DRE, resulting in significant changes in spectral power of SEEG. A larger sample cohort and pursuing optimal sonication parameters will be required to elucidate the neuromodulatory effects of FUS when used for seizure control.",
author = "Lee, {Cheng Chia} and Chou, {Chien Chen} and Hsiao, {Fu Jung} and Chen, {Yi Hsiu} and Lin, {Chun Fu} and Chen, {Ching Jen} and Peng, {Syu Jyun} and Liu, {Hao Li} and Yu, {Hsiang Yu}",
note = "Funding Information: This study was funded by NaviFUS Corporation; this involved only technique support, not study design, patient enrollment, patient outcome analysis, or interpretation of data. Although this is an industry‐sponsored study, the principal investigator and coinvestigators had full power to handle the study without any interference from company, including report writing and the decision to submit the paper for publication. The study was also supported in part by the Taiwan Ministry of Science and Technology (107‐2314‐B‐075‐059‐MY3 and 109‐2314‐B‐075‐053) and National Health Research Institutes (NHRI‐EX109‐10905NI, NHRI‐EX110‐11006NC). The support was mainly in personnel, the clinical database, and supplies related to SEEG. Funding Information: This study was funded by NaviFUS Corporation; this involved only technique support, not study design, patient enrollment, patient outcome analysis, or interpretation of data. Although this is an industry-sponsored study, the principal investigator and coinvestigators had full power to handle the study without any interference from company, including report writing and the decision to submit the paper for publication. The study was also supported in part by the Taiwan Ministry of Science and Technology (107-2314-B-075-059-MY3 and 109-2314-B-075-053) and National Health Research Institutes (NHRI-EX109-10905NI, NHRI-EX110-11006NC). The support was mainly in personnel, the clinical database, and supplies related to SEEG. The authors would like to acknowledge the contribution of the Brain Research Center, National Yang Ming Chiao Tung University, through the Featured Areas Research Center Program within the framework of the Higher Education Sprout Project of the Ministry of Education of Taiwan. We are grateful to our research assistant, Li-Chun Wang, for data recording and transcription. Funding Information: The authors would like to acknowledge the contribution of the Brain Research Center, National Yang Ming Chiao Tung University, through the Featured Areas Research Center Program within the framework of the Higher Education Sprout Project of the Ministry of Education of Taiwan. We are grateful to our research assistant, Li‐Chun Wang, for data recording and transcription. Publisher Copyright: {\textcopyright} 2021 The Authors. Epilepsia published by Wiley Periodicals LLC on behalf of International League Against Epilepsy",
year = "2022",
month = jan,
doi = "10.1111/epi.17105",
language = "English",
volume = "63",
pages = "162--175",
journal = "Epilepsia",
issn = "0013-9580",
publisher = "Wiley-Blackwell",
number = "1",
}