Phytocompounds from Vitis kelungensis stem prevent carbon tetrachloride-induced acute liver injury in mice

Chi Chang Huang; Yu Tang Tung; Kai Chung Cheng; Jyh Horng Wu

doi:10.1016/j.foodchem.2010.09.085

Phytocompounds from Vitis kelungensis stem prevent carbon tetrachloride-induced acute liver injury in mice

Chi Chang Huang, Yu Tang Tung, Kai Chung Cheng, Jyh Horng Wu

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Vitis thunbergii, Vitis flexuosa, and Vitis kelungensis are three common wild grapes in Taiwan and have been used as a traditional medicine for inflammatory disorders. However, the potential bioactivities of these wild grapes have not been studied to date. In this study, anti-inflammatory activities and hepatoprotective properties of these three wild grapes were assessed by in vitro and in vivo assays, respectively. Results revealed that the methanolic extract of V. kelungensis stem (VKS) strongly suppressed NO production in lipopolysaccharide (LPS)-stimulated murine macrophages. And among all fractions derived from VKS, the EtOAc fraction exhibited the best inhibitory activity. In addition, VKS and its major resveratrol derivatives, (-)-ε-viniferin and 2-(4-hydroxyphenyl)-2,3-dihydrobenzo[b]furan-3,4,6-triol, can prevent CCl₄-induced liver injury and aminotransferase activities in mice, which were comparable to that of silymarin or resveratrol, the natural remedies for liver diseases.

Original language	English
Pages (from-to)	726-731
Number of pages	6
Journal	Food Chemistry
Volume	125
Issue number	2
DOIs	https://doi.org/10.1016/j.foodchem.2010.09.085
Publication status	Published - Mar 15 2011
Externally published	Yes

Keywords

Hepatoprotection
Resveratrol derivatives
Stem
Vitis kelungensis
Wild grape

ASJC Scopus subject areas

Food Science
Analytical Chemistry

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10.1016/j.foodchem.2010.09.085

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title = "Phytocompounds from Vitis kelungensis stem prevent carbon tetrachloride-induced acute liver injury in mice",

abstract = "Vitis thunbergii, Vitis flexuosa, and Vitis kelungensis are three common wild grapes in Taiwan and have been used as a traditional medicine for inflammatory disorders. However, the potential bioactivities of these wild grapes have not been studied to date. In this study, anti-inflammatory activities and hepatoprotective properties of these three wild grapes were assessed by in vitro and in vivo assays, respectively. Results revealed that the methanolic extract of V. kelungensis stem (VKS) strongly suppressed NO production in lipopolysaccharide (LPS)-stimulated murine macrophages. And among all fractions derived from VKS, the EtOAc fraction exhibited the best inhibitory activity. In addition, VKS and its major resveratrol derivatives, (-)-ε-viniferin and 2-(4-hydroxyphenyl)-2,3-dihydrobenzo[b]furan-3,4,6-triol, can prevent CCl4-induced liver injury and aminotransferase activities in mice, which were comparable to that of silymarin or resveratrol, the natural remedies for liver diseases.",

keywords = "Hepatoprotection, Resveratrol derivatives, Stem, Vitis kelungensis, Wild grape",

author = "Huang, {Chi Chang} and Tung, {Yu Tang} and Cheng, {Kai Chung} and Wu, {Jyh Horng}",

year = "2011",

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doi = "10.1016/j.foodchem.2010.09.085",

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AU - Huang, Chi Chang

AU - Tung, Yu Tang

AU - Cheng, Kai Chung

AU - Wu, Jyh Horng

PY - 2011/3/15

Y1 - 2011/3/15

N2 - Vitis thunbergii, Vitis flexuosa, and Vitis kelungensis are three common wild grapes in Taiwan and have been used as a traditional medicine for inflammatory disorders. However, the potential bioactivities of these wild grapes have not been studied to date. In this study, anti-inflammatory activities and hepatoprotective properties of these three wild grapes were assessed by in vitro and in vivo assays, respectively. Results revealed that the methanolic extract of V. kelungensis stem (VKS) strongly suppressed NO production in lipopolysaccharide (LPS)-stimulated murine macrophages. And among all fractions derived from VKS, the EtOAc fraction exhibited the best inhibitory activity. In addition, VKS and its major resveratrol derivatives, (-)-ε-viniferin and 2-(4-hydroxyphenyl)-2,3-dihydrobenzo[b]furan-3,4,6-triol, can prevent CCl4-induced liver injury and aminotransferase activities in mice, which were comparable to that of silymarin or resveratrol, the natural remedies for liver diseases.

AB - Vitis thunbergii, Vitis flexuosa, and Vitis kelungensis are three common wild grapes in Taiwan and have been used as a traditional medicine for inflammatory disorders. However, the potential bioactivities of these wild grapes have not been studied to date. In this study, anti-inflammatory activities and hepatoprotective properties of these three wild grapes were assessed by in vitro and in vivo assays, respectively. Results revealed that the methanolic extract of V. kelungensis stem (VKS) strongly suppressed NO production in lipopolysaccharide (LPS)-stimulated murine macrophages. And among all fractions derived from VKS, the EtOAc fraction exhibited the best inhibitory activity. In addition, VKS and its major resveratrol derivatives, (-)-ε-viniferin and 2-(4-hydroxyphenyl)-2,3-dihydrobenzo[b]furan-3,4,6-triol, can prevent CCl4-induced liver injury and aminotransferase activities in mice, which were comparable to that of silymarin or resveratrol, the natural remedies for liver diseases.

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Phytocompounds from Vitis kelungensis stem prevent carbon tetrachloride-induced acute liver injury in mice

Abstract

Keywords

ASJC Scopus subject areas

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