Phyto-SERM constitutes from Flemingia macrophylla

Wan Chun Lai, Ya Ting Tsui, Abdel Nasser B. Singab, Mohamed El-Shazly, Ying Chi Du, Tsong Long Hwang, Chin Chung Wu, Ming Hong Yen, Ching Kuo Lee, Ming Feng Hou, Yang Chang Wu, Fang Rong Chang

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)


The methanolic extract of Flemingia macrophylla roots exhibited significant estrogenic activity in the transgenic plant assay system which was comparable to the activity of soybean extract. Utilizing estrogenic activity-guided fractionation, one new compound, fleminigin, together with 23 known compounds were isolated from F. macrophylla roots' methanolic extract. The structure of the new compound was identified based on intensive spectroscopic analysis and the full spectral data for one of the isolated compounds, flemichin E, was introduced for the first time in the current investigation. The estrogenic and anti-estrogenic activities of the isolated compounds were evaluated revealing that the isolated isoflavonoids may act as partial estrogen agonists, as well as antagonists. Additionally, the anti-inflammatory and the cytotoxic activities of the isolated compounds were studied. These results suggested the potential applications of F. macrophylla extract and its isolated compounds as selective estrogen receptor modulators (SERMs).

Original languageEnglish
Pages (from-to)15578-15594
Number of pages17
JournalInternational journal of molecular sciences
Issue number8
Publication statusPublished - 2013


  • Flemichin E
  • Flemingia macrophylla
  • Fleminigin
  • Menopausal
  • Phytoestrogen
  • pER8:GUS

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


Dive into the research topics of 'Phyto-SERM constitutes from Flemingia macrophylla'. Together they form a unique fingerprint.

Cite this