TY - JOUR
T1 - Physical activity of ≥7.5 met-h/week is significantly associated with a decreased risk of cervical neoplasia
AU - Chang, Ching Wen
AU - Yang, Shun-Fa
AU - Gordon, Christopher J
AU - Liao, Wen Chun
AU - Niu, Shu Fen
AU - Wang, Cheng Wei
AU - Tsai, Hsiu Ting
N1 - Funding Information:
Funding: This study was funded by the Ministry of Science and Technology, Taiwan. Grant number MOST 103-2314-B-040-005-MY3 and MOST 106-2314-B-038-013-MY3. The article publishing charge was funded by MOST 106-2314-B-038-013-MY3.
Funding Information:
This study was funded by the Ministry of Science and Technology, Taiwan. Grant number MOST 103-2314-B-040-005-MY3 and MOST 106-2314-B-038-013-MY3. The article publishing charge was funded by MOST 106-2314-B-038-013-MY3. We gratefully acknowledge the physicians and nurses of Taipei Medical University Hospital (Taipei, Taiwan) for their assistance with recruiting study participants.
Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2020/9
Y1 - 2020/9
N2 - Cervical cancer is one of the most prevalent malignant neoplasms worldwide. We investigated whether leisure-time physical activity is sufficient to decrease the cervical neoplasia risk and provide suggested guidance of metabolic equivalents of task–hours per week (MET-h/week) spent on leisure-time physical activity to prevent cervical neoplasia. Ultimately, 433 participants, including 126 participants with cervical intraepithelial neoplasia I or higher disease (≥CIN 1) and 307 healthy controls, were recruited. All participants completed a standardized questionnaire about leisure-time physical activity engagement (MET-h/week) and a general health questionnaire and had cervical specimens taken to detect human papillomavirus (HPV) infection. CIN 1 staging was identified from the specimens. Participants with physical activity of ≥3.75 MET-h/week had a significantly lower CIN risk compared to those with physical activity of <3.75 MET-h/week (p = 0.01). However, among participants with HPV infection or smokers, the minimal requirement of leisure-time physical actively to lessen the CIN risk was ≥7.5 MET-h/week. Lifetime leisure-time physical activity of ≥0.12 MET-h/week–year also significantly decreased the CIN risk, but women with HPV infection needed ≥13.2 MET-h/week–year to protect them from a CIN risk. We concluded that regular leisure-time physical activity of ≥7.5 MET-h/week and sustained lifetime leisure-time physical activity ≥13.2 MET-h/week–year are vital factors for protecting women against cervical neoplasia risk.
AB - Cervical cancer is one of the most prevalent malignant neoplasms worldwide. We investigated whether leisure-time physical activity is sufficient to decrease the cervical neoplasia risk and provide suggested guidance of metabolic equivalents of task–hours per week (MET-h/week) spent on leisure-time physical activity to prevent cervical neoplasia. Ultimately, 433 participants, including 126 participants with cervical intraepithelial neoplasia I or higher disease (≥CIN 1) and 307 healthy controls, were recruited. All participants completed a standardized questionnaire about leisure-time physical activity engagement (MET-h/week) and a general health questionnaire and had cervical specimens taken to detect human papillomavirus (HPV) infection. CIN 1 staging was identified from the specimens. Participants with physical activity of ≥3.75 MET-h/week had a significantly lower CIN risk compared to those with physical activity of <3.75 MET-h/week (p = 0.01). However, among participants with HPV infection or smokers, the minimal requirement of leisure-time physical actively to lessen the CIN risk was ≥7.5 MET-h/week. Lifetime leisure-time physical activity of ≥0.12 MET-h/week–year also significantly decreased the CIN risk, but women with HPV infection needed ≥13.2 MET-h/week–year to protect them from a CIN risk. We concluded that regular leisure-time physical activity of ≥7.5 MET-h/week and sustained lifetime leisure-time physical activity ≥13.2 MET-h/week–year are vital factors for protecting women against cervical neoplasia risk.
KW - Cervical neoplasia
KW - Human papillomavirus (HPV)
KW - Leisure-time physical activity
KW - Metabolic equivalent of task–hours per week (MET-h/week)
UR - http://www.scopus.com/inward/record.url?scp=85104383134&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85104383134&partnerID=8YFLogxK
U2 - 10.3390/healthcare8030260
DO - 10.3390/healthcare8030260
M3 - Article
C2 - 32785028
SN - 2227-9032
VL - 8
JO - Healthcare (Basel, Switzerland)
JF - Healthcare (Basel, Switzerland)
IS - 3
M1 - 260
ER -