Physical activity of ≥7.5 met-h/week is significantly associated with a decreased risk of cervical neoplasia

Ching Wen Chang, Shun-Fa Yang, Christopher J Gordon, Wen Chun Liao, Shu Fen Niu, Cheng Wei Wang, Hsiu Ting Tsai

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Cervical cancer is one of the most prevalent malignant neoplasms worldwide. We investigated whether leisure-time physical activity is sufficient to decrease the cervical neoplasia risk and provide suggested guidance of metabolic equivalents of task–hours per week (MET-h/week) spent on leisure-time physical activity to prevent cervical neoplasia. Ultimately, 433 participants, including 126 participants with cervical intraepithelial neoplasia I or higher disease (≥CIN 1) and 307 healthy controls, were recruited. All participants completed a standardized questionnaire about leisure-time physical activity engagement (MET-h/week) and a general health questionnaire and had cervical specimens taken to detect human papillomavirus (HPV) infection. CIN 1 staging was identified from the specimens. Participants with physical activity of ≥3.75 MET-h/week had a significantly lower CIN risk compared to those with physical activity of <3.75 MET-h/week (p = 0.01). However, among participants with HPV infection or smokers, the minimal requirement of leisure-time physical actively to lessen the CIN risk was ≥7.5 MET-h/week. Lifetime leisure-time physical activity of ≥0.12 MET-h/week–year also significantly decreased the CIN risk, but women with HPV infection needed ≥13.2 MET-h/week–year to protect them from a CIN risk. We concluded that regular leisure-time physical activity of ≥7.5 MET-h/week and sustained lifetime leisure-time physical activity ≥13.2 MET-h/week–year are vital factors for protecting women against cervical neoplasia risk.

Original languageEnglish
Article number260
JournalHealthcare (Basel, Switzerland)
Issue number3
Publication statusPublished - Sept 2020


  • Cervical neoplasia
  • Human papillomavirus (HPV)
  • Leisure-time physical activity
  • Metabolic equivalent of task–hours per week (MET-h/week)

ASJC Scopus subject areas

  • Health Informatics
  • Health Policy
  • Health Information Management
  • Leadership and Management


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