Photoreactivity of 5-iodouracil-containing DNA-Sso7d complex.

T. Oyoshi, H. Sugiyama, A. H. Wang

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


X-ray structure of DNA-Sso7d complex indicated that binding of this protein causes sharp DNA bending. In order to examine whether this protein also causes DNA bending in solution, photoreactions of 1U-substituted DNA in the presence and the absence of Sso7d protein were investigated. It was found that the unusual intrastrand hydrogen abstraction at methyl of adjacent thymine occurred efficiently at the observed bending site of crystal structure.

Original languageEnglish
Pages (from-to)171-172
Number of pages2
JournalNucleic acids symposium series
Issue number42
Publication statusPublished - 1999
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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