Photoproducts of naproxen in alcoholic solvents

Hsin Tsung Ho, An-Bang Wu, Pen Yuan Lin, Jen Ai Lee, Pen Yueh Hung

Research output: Chapter in Book/Report/Conference proceedingChapter


A sample of 5 mM naproxen in methanol or ethanol was photoirradiated with a Hanovia 200 W high-pressure quartz Hg lamp. In total, 6 photoproducts derived from each sample were observed from the HPLC chromatograms. Four major photoproducts were separated, and their structures elucidated by EI-MS and various spectroscopic methods. A reaction scheme of naproxen in alcoholic solvents is proposed: the photochemical reaction routes occur mainly via decarboxylation and esterification, followed by oxidation with singlet oxygen to produce an alcohol and a ketone.

Original languageEnglish
Title of host publicationBiomedical Chromatography
PublisherNova Science Publishers, Inc.
Number of pages12
ISBN (Electronic)9781616684709
ISBN (Print)9781607412915
Publication statusPublished - Jan 1 2010


  • EI-MS
  • HPLC
  • Naproxen
  • Photochemistry

ASJC Scopus subject areas

  • General Agricultural and Biological Sciences
  • General Biochemistry,Genetics and Molecular Biology


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