Photoproducts of naproxen in alcoholic solvents

Hsin Tsung Ho; An-Bang Wu; Pen Yuan Lin; Jen Ai Lee; Pen Yueh Hung

Photoproducts of naproxen in alcoholic solvents

Hsin Tsung Ho, An-Bang Wu, Pen Yuan Lin, Jen Ai Lee, Pen Yueh Hung

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

A sample of 5 mM naproxen in methanol or ethanol was photoirradiated with a Hanovia 200 W high-pressure quartz Hg lamp. In total, 6 photoproducts derived from each sample were observed from the HPLC chromatograms. Four major photoproducts were separated, and their structures elucidated by EI-MS and various spectroscopic methods. A reaction scheme of naproxen in alcoholic solvents is proposed: the photochemical reaction routes occur mainly via decarboxylation and esterification, followed by oxidation with singlet oxygen to produce an alcohol and a ketone.

Original language	English
Title of host publication	Biomedical Chromatography
Publisher	Nova Science Publishers, Inc.
Pages	159-170
Number of pages	12
ISBN (Electronic)	9781616684709
ISBN (Print)	9781607412915
Publication status	Published - Jan 1 2010

Keywords

EI-MS
HPLC
Naproxen
Photochemistry

ASJC Scopus subject areas

General Agricultural and Biological Sciences
General Biochemistry,Genetics and Molecular Biology

Cite this

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title = "Photoproducts of naproxen in alcoholic solvents",

abstract = "A sample of 5 mM naproxen in methanol or ethanol was photoirradiated with a Hanovia 200 W high-pressure quartz Hg lamp. In total, 6 photoproducts derived from each sample were observed from the HPLC chromatograms. Four major photoproducts were separated, and their structures elucidated by EI-MS and various spectroscopic methods. A reaction scheme of naproxen in alcoholic solvents is proposed: the photochemical reaction routes occur mainly via decarboxylation and esterification, followed by oxidation with singlet oxygen to produce an alcohol and a ketone.",

keywords = "EI-MS, HPLC, Naproxen, Photochemistry",

author = "Ho, {Hsin Tsung} and An-Bang Wu and Lin, {Pen Yuan} and Lee, {Jen Ai} and Hung, {Pen Yueh}",

note = "Publisher Copyright: {\textcopyright} 2010 Nova Science Publishers, Inc.",

year = "2010",

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day = "1",

language = "English",

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pages = "159--170",

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T1 - Photoproducts of naproxen in alcoholic solvents

AU - Ho, Hsin Tsung

AU - Wu, An-Bang

AU - Lin, Pen Yuan

AU - Lee, Jen Ai

AU - Hung, Pen Yueh

PY - 2010/1/1

Y1 - 2010/1/1

N2 - A sample of 5 mM naproxen in methanol or ethanol was photoirradiated with a Hanovia 200 W high-pressure quartz Hg lamp. In total, 6 photoproducts derived from each sample were observed from the HPLC chromatograms. Four major photoproducts were separated, and their structures elucidated by EI-MS and various spectroscopic methods. A reaction scheme of naproxen in alcoholic solvents is proposed: the photochemical reaction routes occur mainly via decarboxylation and esterification, followed by oxidation with singlet oxygen to produce an alcohol and a ketone.

AB - A sample of 5 mM naproxen in methanol or ethanol was photoirradiated with a Hanovia 200 W high-pressure quartz Hg lamp. In total, 6 photoproducts derived from each sample were observed from the HPLC chromatograms. Four major photoproducts were separated, and their structures elucidated by EI-MS and various spectroscopic methods. A reaction scheme of naproxen in alcoholic solvents is proposed: the photochemical reaction routes occur mainly via decarboxylation and esterification, followed by oxidation with singlet oxygen to produce an alcohol and a ketone.

KW - EI-MS

KW - HPLC

KW - Naproxen

KW - Photochemistry

UR - http://www.scopus.com/inward/record.url?scp=85016789591&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85016789591&partnerID=8YFLogxK

M3 - Chapter

AN - SCOPUS:85016789591

SN - 9781607412915

SP - 159

EP - 170

BT - Biomedical Chromatography

PB - Nova Science Publishers, Inc.

ER -

Photoproducts of naproxen in alcoholic solvents

Abstract

Keywords

ASJC Scopus subject areas

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