Phosphorylation-dependent SUMOylation of the transcription factor NF-E2

Yee Fun Su, Yu Chiau Shyu, Che Kun James Shen, Jaulang Hwang

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


Nuclear factor erythroid-derived 2 (NF-E2), a heterodimer composed of p45 and p18, is a transcriptional activator in hematopoietic progenitors. The transcriptional activity of NF-E2 is not only upregulated by SUMOylation but also stimulated by the cAMP-dependent protein kinase A (PKA). However, the relationship between SUMOylation and phosphorylation in the activation of NF-E2 is unclear. In the present studies, we have demonstrated that PKA enhances NF-E2 SUMOylation in an in vitro system using purified proteins, suggesting a possible mechanism for PKA-dependent activation of the NF-E2 transcription factor through SUMOylation.

Original languageEnglish
Article numbere44608
JournalPLoS ONE
Issue number9
Publication statusPublished - Sept 10 2012

ASJC Scopus subject areas

  • General
  • General Biochemistry,Genetics and Molecular Biology
  • General Agricultural and Biological Sciences


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