Pharmacokinetic model of daily selenium intake from contaminated seafood in Taiwan

Ling Chu Chien; Ching-Ying Yeh; Shih Yi Huang; Ming-Che Hsieh; Bor Cheng Han

doi:10.1016/S0048-9697(03)00134-7

Pharmacokinetic model of daily selenium intake from contaminated seafood in Taiwan

Ling Chu Chien, Ching-Ying Yeh, Shih Yi Huang, Ming-Che Hsieh, Bor Cheng Han

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

Contaminated seafood has been reported as an important source of human exposure to metals in Taiwan. Seafood represents a non-negligible source of selenium in the human diet. This study was designed to determine the concentration of selenium in different types of seafood and predict the concentration of selenium in the blood of Taiwanese using a one-compartment steady-state pharmacokinetic (PK) model. Samples involved three subgroups, including fish, crustaceans and bivalve molluscs. Quantitative analysis for selenium was performed using an ICP-AES (Perkin Elmer) instrument. Selenium concentrations in seafood ranged from 0.63 to 2.01 μg/g wet wt. The highest selenium concentration found in fish was 2.01±0.36 μg/g wet wt in Salmo salar Linnaeus. In general, selenium concentration increased in the order of bivalve molluscs

Original language	English
Pages (from-to)	57-64
Number of pages	8
Journal	Science of the Total Environment
Volume	311
Issue number	1-3
DOIs	https://doi.org/10.1016/S0048-9697(03)00134-7
Publication status	Published - Jul 20 2003

Keywords

Daily intake
Pharmacokinetic model
Seafood
Selenium

ASJC Scopus subject areas

Environmental Chemistry
General Environmental Science

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10.1016/S0048-9697(03)00134-7

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title = "Pharmacokinetic model of daily selenium intake from contaminated seafood in Taiwan",

abstract = "Contaminated seafood has been reported as an important source of human exposure to metals in Taiwan. Seafood represents a non-negligible source of selenium in the human diet. This study was designed to determine the concentration of selenium in different types of seafood and predict the concentration of selenium in the blood of Taiwanese using a one-compartment steady-state pharmacokinetic (PK) model. Samples involved three subgroups, including fish, crustaceans and bivalve molluscs. Quantitative analysis for selenium was performed using an ICP-AES (Perkin Elmer) instrument. Selenium concentrations in seafood ranged from 0.63 to 2.01 μg/g wet wt. The highest selenium concentration found in fish was 2.01±0.36 μg/g wet wt in Salmo salar Linnaeus. In general, selenium concentration increased in the order of bivalve molluscs",

keywords = "Daily intake, Pharmacokinetic model, Seafood, Selenium, Daily intake, Pharmacokinetic model, Seafood, Selenium",

author = "Chien, {Ling Chu} and Ching-Ying Yeh and Huang, {Shih Yi} and Ming-Che Hsieh and Han, {Bor Cheng}",

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AU - Yeh, Ching-Ying

AU - Huang, Shih Yi

AU - Hsieh, Ming-Che

AU - Han, Bor Cheng

PY - 2003/7/20

Y1 - 2003/7/20

N2 - Contaminated seafood has been reported as an important source of human exposure to metals in Taiwan. Seafood represents a non-negligible source of selenium in the human diet. This study was designed to determine the concentration of selenium in different types of seafood and predict the concentration of selenium in the blood of Taiwanese using a one-compartment steady-state pharmacokinetic (PK) model. Samples involved three subgroups, including fish, crustaceans and bivalve molluscs. Quantitative analysis for selenium was performed using an ICP-AES (Perkin Elmer) instrument. Selenium concentrations in seafood ranged from 0.63 to 2.01 μg/g wet wt. The highest selenium concentration found in fish was 2.01±0.36 μg/g wet wt in Salmo salar Linnaeus. In general, selenium concentration increased in the order of bivalve molluscs

AB - Contaminated seafood has been reported as an important source of human exposure to metals in Taiwan. Seafood represents a non-negligible source of selenium in the human diet. This study was designed to determine the concentration of selenium in different types of seafood and predict the concentration of selenium in the blood of Taiwanese using a one-compartment steady-state pharmacokinetic (PK) model. Samples involved three subgroups, including fish, crustaceans and bivalve molluscs. Quantitative analysis for selenium was performed using an ICP-AES (Perkin Elmer) instrument. Selenium concentrations in seafood ranged from 0.63 to 2.01 μg/g wet wt. The highest selenium concentration found in fish was 2.01±0.36 μg/g wet wt in Salmo salar Linnaeus. In general, selenium concentration increased in the order of bivalve molluscs

KW - Daily intake

KW - Pharmacokinetic model

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Pharmacokinetic model of daily selenium intake from contaminated seafood in Taiwan

Abstract

Keywords

ASJC Scopus subject areas

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