Isoliquiritigenin (20,40,4-trihydroxychalcone, ISL), one of the most important bioactive compounds with a chalcone structure, is derived from licorice root. Licorice is commonly known as Glycyrrhiza, including Glycyrrhiza uralensis, Glycyrrhiza radix, and Glycyrrhiza glabra, which are generally available in common foods and Chinese herbal medicines based on a wide variety of biological functions and pharmacological effects, and its derivative (ISL) is utilized as a food additive and adjunct disease treatment. In this review, we summarized the progress over the last 10 years in the targeted pathways and molecular mechanisms of ISL that are involved in the regulation of the onset and progression of different types of cancers.

Original languageEnglish
Article number115
Pages (from-to)1-37
Number of pages37
Issue number1
Publication statusPublished - Jan 1 2021


  • Apoptosis
  • Cancer
  • Cell signaling
  • Isoliquiritigenin

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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