Persistent inflammation and its relationship to leptin and insulin in phases of bipolar disorder from acute depression to full remission

Shang Ying Tsai; Kuo Hsuan Chung; Shou-Hung Huang; Pao Huan Chen; Hsin Chien Lee; Chian Jue Kuo

doi:10.1111/bdi.12240

Persistent inflammation and its relationship to leptin and insulin in phases of bipolar disorder from acute depression to full remission

Shang Ying Tsai, Kuo Hsuan Chung, Shou-Hung Huang, Pao Huan Chen, Hsin Chien Lee, Chian Jue Kuo

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

Objective: A proinflammatory phase with various immunomodulatory mechanisms has been noted in bipolar mania and major depression. Weight gain and increased production of leptin may be associated with immunomodulation and insulin resistance in bipolar disorder. However, immunomodulation and its linkage with leptin and insulin in the depressive episode of bipolar disorder remain unclear. We investigated alterations in inflammatory markers and their relationship with leptin and insulin levels in patients with phases of bipolar disorder from acute depression to full remission. Methods: Thirty-two physically healthy bipolar I depressed patients aged

Original language	English
Pages (from-to)	800-808
Number of pages	9
Journal	Bipolar Disorders
Volume	16
Issue number	8
DOIs	https://doi.org/10.1111/bdi.12240
Publication status	Published - Dec 1 2014

Keywords

Bipolar depression
High-sensitivity C-reactive protein (hs-CRP)
Inflammation
Interleukin-1 receptor antagonist (IL-1Ra)
Soluble interleukin-2 receptor (sIL-2R)
Soluble tumor necrosis factor receptor 1 (sTNF-R1)
sIL-6R

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/bdi.12240

Cite this

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abstract = "Objective: A proinflammatory phase with various immunomodulatory mechanisms has been noted in bipolar mania and major depression. Weight gain and increased production of leptin may be associated with immunomodulation and insulin resistance in bipolar disorder. However, immunomodulation and its linkage with leptin and insulin in the depressive episode of bipolar disorder remain unclear. We investigated alterations in inflammatory markers and their relationship with leptin and insulin levels in patients with phases of bipolar disorder from acute depression to full remission. Methods: Thirty-two physically healthy bipolar I depressed patients aged ",

keywords = "Bipolar depression, High-sensitivity C-reactive protein (hs-CRP), Inflammation, Interleukin-1 receptor antagonist (IL-1Ra), Soluble interleukin-2 receptor (sIL-2R), Soluble tumor necrosis factor receptor 1 (sTNF-R1), sIL-6R",

author = "Tsai, {Shang Ying} and Chung, {Kuo Hsuan} and Shou-Hung Huang and Chen, {Pao Huan} and Lee, {Hsin Chien} and Kuo, {Chian Jue}",

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doi = "10.1111/bdi.12240",

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T1 - Persistent inflammation and its relationship to leptin and insulin in phases of bipolar disorder from acute depression to full remission

AU - Tsai, Shang Ying

AU - Chung, Kuo Hsuan

AU - Huang, Shou-Hung

AU - Chen, Pao Huan

AU - Lee, Hsin Chien

AU - Kuo, Chian Jue

PY - 2014/12/1

Y1 - 2014/12/1

N2 - Objective: A proinflammatory phase with various immunomodulatory mechanisms has been noted in bipolar mania and major depression. Weight gain and increased production of leptin may be associated with immunomodulation and insulin resistance in bipolar disorder. However, immunomodulation and its linkage with leptin and insulin in the depressive episode of bipolar disorder remain unclear. We investigated alterations in inflammatory markers and their relationship with leptin and insulin levels in patients with phases of bipolar disorder from acute depression to full remission. Methods: Thirty-two physically healthy bipolar I depressed patients aged

AB - Objective: A proinflammatory phase with various immunomodulatory mechanisms has been noted in bipolar mania and major depression. Weight gain and increased production of leptin may be associated with immunomodulation and insulin resistance in bipolar disorder. However, immunomodulation and its linkage with leptin and insulin in the depressive episode of bipolar disorder remain unclear. We investigated alterations in inflammatory markers and their relationship with leptin and insulin levels in patients with phases of bipolar disorder from acute depression to full remission. Methods: Thirty-two physically healthy bipolar I depressed patients aged

KW - Bipolar depression

KW - High-sensitivity C-reactive protein (hs-CRP)

KW - Inflammation

KW - Interleukin-1 receptor antagonist (IL-1Ra)

KW - Soluble interleukin-2 receptor (sIL-2R)

KW - Soluble tumor necrosis factor receptor 1 (sTNF-R1)

KW - sIL-6R

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Persistent inflammation and its relationship to leptin and insulin in phases of bipolar disorder from acute depression to full remission

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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