Objective: A proinflammatory phase with various immunomodulatory mechanisms has been noted in bipolar mania and major depression. Weight gain and increased production of leptin may be associated with immunomodulation and insulin resistance in bipolar disorder. However, immunomodulation and its linkage with leptin and insulin in the depressive episode of bipolar disorder remain unclear. We investigated alterations in inflammatory markers and their relationship with leptin and insulin levels in patients with phases of bipolar disorder from acute depression to full remission. Methods: Thirty-two physically healthy bipolar I depressed patients aged

Original languageEnglish
Pages (from-to)800-808
Number of pages9
JournalBipolar Disorders
Issue number8
Publication statusPublished - Dec 1 2014


  • Bipolar depression
  • High-sensitivity C-reactive protein (hs-CRP)
  • Inflammation
  • Interleukin-1 receptor antagonist (IL-1Ra)
  • Soluble interleukin-2 receptor (sIL-2R)
  • Soluble tumor necrosis factor receptor 1 (sTNF-R1)
  • sIL-6R

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry


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