Abstract
In 500 children aged ≤10 years after 13-valent pneumococcal conjugate vaccine (PCV)13 immunisation in different schedules, serotypes 19A-specific and 19F-specific immunoglobulin G (IgG) were predicted to persist above 0.35 μg/mL for ≥10 years in all groups, likely due to PCV13-induced memory with natural boosting from residual diseases and colonisation. Generally, serotype-specific IgG could persist above 0.35 μg/mL longer (≥5 years) in the catch-up group than in the 2+1 and 3+1 immunisation groups. 14.5% of the carriage isolates belonged to PCV13 serotypes; statistical analysis revealed that a high serum IgG level (>10.96 μg/mL) will be required to eliminate the point-prevalence nasopharyngeal carriage of serotype 19A.
Original language | English |
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Pages (from-to) | 689-692 |
Number of pages | 4 |
Journal | Thorax |
Volume | 75 |
Issue number | 8 |
DOIs | |
Publication status | Published - Aug 1 2020 |
Externally published | Yes |
Keywords
- bacterial infection
- clinical epidemiology
- infection control
- paediatric lung disaese
- pneumonia
- respiratory infection
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine