Permeation of biological compounds through porous poly(l-lactic acid) (PLLA) microtube array membranes (MTAMs)

Wei Chiang Hung; Lin Hong Lin; Wen Chin Tsen; Han Shian Shie; Hsien Lung Chiu; Thomas C K Yang; Chien Chung Chen

doi:10.1016/j.eurpolymj.2015.03.055

Permeation of biological compounds through porous poly(l-lactic acid) (PLLA) microtube array membranes (MTAMs)

Wei Chiang Hung, Lin Hong Lin, Wen Chin Tsen, Han Shian Shie, Hsien Lung Chiu, Thomas C K Yang, Chien Chung Chen

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

In this study, the permeation of two biological compounds through a novel porous poly(l-lactic acid) (PLLA) microtube array membrane (MTAM) were investigated. Glucose and bovine serum albumin (BSA) were permeated through PLLA MTAMs to simulate the transportation of biological compounds during nerve regeneration. PLLA MTAMs with various porous wall structures were prepared by the addition of porogen. Electrospinning process was conducted to produce solid MTAMs. Porous MTAMs were obtained by washing off the porogen. Permeation of BSA and glucose were investigated by utilizing a home-made permeation unit at 37 °C for both inflow and outflow. The permeation rate increased with the porosity of the MTAM; with the inflow rate faster than the outflow rate for both compounds suggesting a diffusive permeation. The rate of BSA permeation was faster than that of glucose. Fourier transfer infra-red (FTIR) spectra of the two compounds permeated through PLLA membranes were obtained to elucidate this phenomena.

Original language	English
Pages (from-to)	166-173
Number of pages	8
Journal	European Polymer Journal
Volume	67
DOIs	https://doi.org/10.1016/j.eurpolymj.2015.03.055
Publication status	Published - Jun 1 2015

Keywords

Electrospinning
Nerve guide conduit (NGC)
Nerve regeneration
PLLA
Permeation
Poly(l-lactic acid)
Porous microtube array membrane (p-MTAM)

ASJC Scopus subject areas

Physics and Astronomy(all)
Organic Chemistry
Polymers and Plastics
Materials Chemistry

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10.1016/j.eurpolymj.2015.03.055

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title = "Permeation of biological compounds through porous poly(l-lactic acid) (PLLA) microtube array membranes (MTAMs)",

abstract = "In this study, the permeation of two biological compounds through a novel porous poly(l-lactic acid) (PLLA) microtube array membrane (MTAM) were investigated. Glucose and bovine serum albumin (BSA) were permeated through PLLA MTAMs to simulate the transportation of biological compounds during nerve regeneration. PLLA MTAMs with various porous wall structures were prepared by the addition of porogen. Electrospinning process was conducted to produce solid MTAMs. Porous MTAMs were obtained by washing off the porogen. Permeation of BSA and glucose were investigated by utilizing a home-made permeation unit at 37 °C for both inflow and outflow. The permeation rate increased with the porosity of the MTAM; with the inflow rate faster than the outflow rate for both compounds suggesting a diffusive permeation. The rate of BSA permeation was faster than that of glucose. Fourier transfer infra-red (FTIR) spectra of the two compounds permeated through PLLA membranes were obtained to elucidate this phenomena.",

keywords = "Electrospinning, Nerve guide conduit (NGC), Nerve regeneration, PLLA, Permeation, Poly(l-lactic acid), Porous microtube array membrane (p-MTAM)",

author = "Hung, {Wei Chiang} and Lin, {Lin Hong} and Tsen, {Wen Chin} and Shie, {Han Shian} and Chiu, {Hsien Lung} and Yang, {Thomas C K} and Chen, {Chien Chung}",

note = "Funding Information: Partial funding from the National Science Council Taiwan (NSC102-2221-E-038-015) is highly appreciated. Acknowledgement is also extended to BioTechOne, Taipei, Taiwan, for providing the PLLA. Publisher Copyright: {\textcopyright} 2015 Elsevier Ltd. All rights reserved. Copyright: Copyright 2015 Elsevier B.V., All rights reserved.",

year = "2015",

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doi = "10.1016/j.eurpolymj.2015.03.055",

language = "English",

volume = "67",

pages = "166--173",

journal = "European Polymer Journal",

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T1 - Permeation of biological compounds through porous poly(l-lactic acid) (PLLA) microtube array membranes (MTAMs)

AU - Hung, Wei Chiang

AU - Lin, Lin Hong

AU - Tsen, Wen Chin

AU - Shie, Han Shian

AU - Chiu, Hsien Lung

AU - Yang, Thomas C K

AU - Chen, Chien Chung

N1 - Funding Information: Partial funding from the National Science Council Taiwan (NSC102-2221-E-038-015) is highly appreciated. Acknowledgement is also extended to BioTechOne, Taipei, Taiwan, for providing the PLLA. Publisher Copyright: © 2015 Elsevier Ltd. All rights reserved. Copyright: Copyright 2015 Elsevier B.V., All rights reserved.

PY - 2015/6/1

Y1 - 2015/6/1

N2 - In this study, the permeation of two biological compounds through a novel porous poly(l-lactic acid) (PLLA) microtube array membrane (MTAM) were investigated. Glucose and bovine serum albumin (BSA) were permeated through PLLA MTAMs to simulate the transportation of biological compounds during nerve regeneration. PLLA MTAMs with various porous wall structures were prepared by the addition of porogen. Electrospinning process was conducted to produce solid MTAMs. Porous MTAMs were obtained by washing off the porogen. Permeation of BSA and glucose were investigated by utilizing a home-made permeation unit at 37 °C for both inflow and outflow. The permeation rate increased with the porosity of the MTAM; with the inflow rate faster than the outflow rate for both compounds suggesting a diffusive permeation. The rate of BSA permeation was faster than that of glucose. Fourier transfer infra-red (FTIR) spectra of the two compounds permeated through PLLA membranes were obtained to elucidate this phenomena.

AB - In this study, the permeation of two biological compounds through a novel porous poly(l-lactic acid) (PLLA) microtube array membrane (MTAM) were investigated. Glucose and bovine serum albumin (BSA) were permeated through PLLA MTAMs to simulate the transportation of biological compounds during nerve regeneration. PLLA MTAMs with various porous wall structures were prepared by the addition of porogen. Electrospinning process was conducted to produce solid MTAMs. Porous MTAMs were obtained by washing off the porogen. Permeation of BSA and glucose were investigated by utilizing a home-made permeation unit at 37 °C for both inflow and outflow. The permeation rate increased with the porosity of the MTAM; with the inflow rate faster than the outflow rate for both compounds suggesting a diffusive permeation. The rate of BSA permeation was faster than that of glucose. Fourier transfer infra-red (FTIR) spectra of the two compounds permeated through PLLA membranes were obtained to elucidate this phenomena.

KW - Electrospinning

KW - Nerve guide conduit (NGC)

KW - Nerve regeneration

KW - PLLA

KW - Permeation

KW - Poly(l-lactic acid)

KW - Porous microtube array membrane (p-MTAM)

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JO - European Polymer Journal

JF - European Polymer Journal

ER -

Permeation of biological compounds through porous poly(l-lactic acid) (PLLA) microtube array membranes (MTAMs)

Abstract

Keywords

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