Abstract
A novel application of intramolecular base catalysis confers enhanced reaction rates for aminolysis ligations between peptide thioesters and peptides bearing N-terminal aspartate or glutamate residues. The broad scope of this process and its application in the total synthesis of the diabetes drug exenatide is demonstrated.
Original language | English |
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Pages (from-to) | 4770-4773 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 13 |
Issue number | 18 |
DOIs | |
Publication status | Published - Sept 16 2011 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry