Peptide ligations accelerated by N-terminal aspartate and glutamate residues

Gemma L. Thomas, Yves S.Y. Hsieh, Candy K.Y. Chun, Zheng Li Cai, Jeffrey R. Reimers, Richard J. Payne

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)


A novel application of intramolecular base catalysis confers enhanced reaction rates for aminolysis ligations between peptide thioesters and peptides bearing N-terminal aspartate or glutamate residues. The broad scope of this process and its application in the total synthesis of the diabetes drug exenatide is demonstrated.

Original languageEnglish
Pages (from-to)4770-4773
Number of pages4
JournalOrganic Letters
Issue number18
Publication statusPublished - Sept 16 2011
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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