PEGylated silica nanoparticles encapsulating multiple magnetite nanocrystals for high-performance microscopic magnetic resonance angiography

Si Han Wu; Chien Yuan Lin; Yann Hung; Wei Chen; Chen Chang; Chung Yuan Mou

doi:10.1002/jbm.b.31874

PEGylated silica nanoparticles encapsulating multiple magnetite nanocrystals for high-performance microscopic magnetic resonance angiography

Si Han Wu, Chien Yuan Lin, Yann Hung, Wei Chen, Chen Chang, Chung Yuan Mou

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

A novel magnetic resonance (MR) angiographic method, 3DΔR2-mMRA (three dimensional and ΔR2 based microscopy magnetic resonance angiography), is developed as a clinical diagnosis for depicting the function and structure of cerebral small vessels. However, the visibility of microvasculatures and the precision of cerebral blood volume calculation greatly rely on the transverse relaxivity and intravascular half-life of contrast agent, respectively. In this work, we report a blood pool contrast agent named H-Fe ₃O ₄@SiO ₂-PEG where multiple Fe ₃O ₄ nanocrystals are encapsulated in a thin silica shell to enhance the T ₂-relaxivity (r ₂ = 342.8 mM ^-1 s ^-1) and poly(ethylene glycol) (PEG) is employed to reduce opsonization and prolong circulation time of nanoparticles. Utilization of the newly developed H-Fe ₃O ₄@SiO ₂-PEG with a novel MR angiographic methodology, a high-resolution MR image of rat cerebral microvasculatures is successfully obtained.

Original language	English
Pages (from-to)	81-88
Number of pages	8
Journal	Journal of Biomedical Materials Research - Part B Applied Biomaterials
Volume	99 B
Issue number	1
DOIs	https://doi.org/10.1002/jbm.b.31874
Publication status	Published - Oct 2011
Externally published	Yes

Keywords

Fe O
MRI
contrast agents
polyethylene glycol
silica

ASJC Scopus subject areas

Biomedical Engineering
Biomaterials

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10.1002/jbm.b.31874

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PEGylated silica nanoparticles encapsulating multiple magnetite nanocrystals for high-performance microscopic magnetic resonance angiography. / Wu, Si Han; Lin, Chien Yuan; Hung, Yann et al.
In: Journal of Biomedical Materials Research - Part B Applied Biomaterials, Vol. 99 B, No. 1, 10.2011, p. 81-88.

Research output: Contribution to journal › Article › peer-review

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abstract = "A novel magnetic resonance (MR) angiographic method, 3DΔR2-mMRA (three dimensional and ΔR2 based microscopy magnetic resonance angiography), is developed as a clinical diagnosis for depicting the function and structure of cerebral small vessels. However, the visibility of microvasculatures and the precision of cerebral blood volume calculation greatly rely on the transverse relaxivity and intravascular half-life of contrast agent, respectively. In this work, we report a blood pool contrast agent named H-Fe 3O 4@SiO 2-PEG where multiple Fe 3O 4 nanocrystals are encapsulated in a thin silica shell to enhance the T 2-relaxivity (r 2 = 342.8 mM -1 s -1) and poly(ethylene glycol) (PEG) is employed to reduce opsonization and prolong circulation time of nanoparticles. Utilization of the newly developed H-Fe 3O 4@SiO 2-PEG with a novel MR angiographic methodology, a high-resolution MR image of rat cerebral microvasculatures is successfully obtained.",

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AU - Hung, Yann

AU - Chen, Wei

AU - Chang, Chen

AU - Mou, Chung Yuan

PY - 2011/10

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N2 - A novel magnetic resonance (MR) angiographic method, 3DΔR2-mMRA (three dimensional and ΔR2 based microscopy magnetic resonance angiography), is developed as a clinical diagnosis for depicting the function and structure of cerebral small vessels. However, the visibility of microvasculatures and the precision of cerebral blood volume calculation greatly rely on the transverse relaxivity and intravascular half-life of contrast agent, respectively. In this work, we report a blood pool contrast agent named H-Fe 3O 4@SiO 2-PEG where multiple Fe 3O 4 nanocrystals are encapsulated in a thin silica shell to enhance the T 2-relaxivity (r 2 = 342.8 mM -1 s -1) and poly(ethylene glycol) (PEG) is employed to reduce opsonization and prolong circulation time of nanoparticles. Utilization of the newly developed H-Fe 3O 4@SiO 2-PEG with a novel MR angiographic methodology, a high-resolution MR image of rat cerebral microvasculatures is successfully obtained.

AB - A novel magnetic resonance (MR) angiographic method, 3DΔR2-mMRA (three dimensional and ΔR2 based microscopy magnetic resonance angiography), is developed as a clinical diagnosis for depicting the function and structure of cerebral small vessels. However, the visibility of microvasculatures and the precision of cerebral blood volume calculation greatly rely on the transverse relaxivity and intravascular half-life of contrast agent, respectively. In this work, we report a blood pool contrast agent named H-Fe 3O 4@SiO 2-PEG where multiple Fe 3O 4 nanocrystals are encapsulated in a thin silica shell to enhance the T 2-relaxivity (r 2 = 342.8 mM -1 s -1) and poly(ethylene glycol) (PEG) is employed to reduce opsonization and prolong circulation time of nanoparticles. Utilization of the newly developed H-Fe 3O 4@SiO 2-PEG with a novel MR angiographic methodology, a high-resolution MR image of rat cerebral microvasculatures is successfully obtained.

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KW - polyethylene glycol

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PEGylated silica nanoparticles encapsulating multiple magnetite nanocrystals for high-performance microscopic magnetic resonance angiography

Abstract

Keywords

ASJC Scopus subject areas

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