Peginterferon α-2b and Acute Allograft Failure in a Heart Transplant Recipient

Bing Yen Wang, Hsiao Huang Chang, I. Ming Chen, Chun Che Shih, An Hang Yang

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


Reports of heart transplant recipients with hepatitis C viral infection treated with peginterferon α-2b and ribavirin are very rare. We report a fatal case of acute allograft failure and hepatitis C viral infection in a 50-year-old orthotopic heart transplant recipient. At autopsy, the patient was found to have patent coronary arteries, diffuse severe fatty degeneration of heart myocytes, and no evidence of cellular or humoral rejection, confirming this as a fatal case of cardiotoxicity from peginterferon α-2b.

Original languageEnglish
Pages (from-to)1645-1647
Number of pages3
JournalAnnals of Thoracic Surgery
Issue number5
Publication statusPublished - May 1 2010
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine


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