Peginterferon α-2b and Acute Allograft Failure in a Heart Transplant Recipient

Bing Yen Wang; Hsiao Huang Chang; I. Ming Chen; Chun Che Shih; An Hang Yang

doi:10.1016/j.athoracsur.2009.09.084

Peginterferon α-2b and Acute Allograft Failure in a Heart Transplant Recipient

Bing Yen Wang, Hsiao Huang Chang, I. Ming Chen, Chun Che Shih, An Hang Yang

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Reports of heart transplant recipients with hepatitis C viral infection treated with peginterferon α-2b and ribavirin are very rare. We report a fatal case of acute allograft failure and hepatitis C viral infection in a 50-year-old orthotopic heart transplant recipient. At autopsy, the patient was found to have patent coronary arteries, diffuse severe fatty degeneration of heart myocytes, and no evidence of cellular or humoral rejection, confirming this as a fatal case of cardiotoxicity from peginterferon α-2b.

Original language	English
Pages (from-to)	1645-1647
Number of pages	3
Journal	Annals of Thoracic Surgery
Volume	89
Issue number	5
DOIs	https://doi.org/10.1016/j.athoracsur.2009.09.084
Publication status	Published - May 1 2010
Externally published	Yes

ASJC Scopus subject areas

Surgery
Pulmonary and Respiratory Medicine
Cardiology and Cardiovascular Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.athoracsur.2009.09.084

Cite this

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title = "Peginterferon α-2b and Acute Allograft Failure in a Heart Transplant Recipient",

abstract = "Reports of heart transplant recipients with hepatitis C viral infection treated with peginterferon α-2b and ribavirin are very rare. We report a fatal case of acute allograft failure and hepatitis C viral infection in a 50-year-old orthotopic heart transplant recipient. At autopsy, the patient was found to have patent coronary arteries, diffuse severe fatty degeneration of heart myocytes, and no evidence of cellular or humoral rejection, confirming this as a fatal case of cardiotoxicity from peginterferon α-2b.",

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AU - Wang, Bing Yen

AU - Chang, Hsiao Huang

AU - Chen, I. Ming

AU - Shih, Chun Che

AU - Yang, An Hang

PY - 2010/5/1

Y1 - 2010/5/1

N2 - Reports of heart transplant recipients with hepatitis C viral infection treated with peginterferon α-2b and ribavirin are very rare. We report a fatal case of acute allograft failure and hepatitis C viral infection in a 50-year-old orthotopic heart transplant recipient. At autopsy, the patient was found to have patent coronary arteries, diffuse severe fatty degeneration of heart myocytes, and no evidence of cellular or humoral rejection, confirming this as a fatal case of cardiotoxicity from peginterferon α-2b.

AB - Reports of heart transplant recipients with hepatitis C viral infection treated with peginterferon α-2b and ribavirin are very rare. We report a fatal case of acute allograft failure and hepatitis C viral infection in a 50-year-old orthotopic heart transplant recipient. At autopsy, the patient was found to have patent coronary arteries, diffuse severe fatty degeneration of heart myocytes, and no evidence of cellular or humoral rejection, confirming this as a fatal case of cardiotoxicity from peginterferon α-2b.

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JO - Annals of Thoracic Surgery

JF - Annals of Thoracic Surgery

IS - 5

ER -

Peginterferon α-2b and Acute Allograft Failure in a Heart Transplant Recipient

Abstract

ASJC Scopus subject areas

UN SDGs

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