Paradoxical cryptococcal immune reconstitution inflammatory syndrome in advanced chronic kidney disease

Chih Chin Kao; Vin Cent Wu; Hsin Yun Sun; Che Hsiung Wu

doi:10.1007/s11255-012-0196-y

Paradoxical cryptococcal immune reconstitution inflammatory syndrome in advanced chronic kidney disease

Chih Chin Kao, Vin Cent Wu, Hsin Yun Sun, Che Hsiung Wu

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Cryptococcal-related immune reconstitution inflammatory syndrome (IRIS) is frequently seen in immunocompromised patients. A 45-year-old man with advanced chronic kidney disease (CKD) received intensive antifungal treatment for pulmonary cryptococcosis. Despite negative pleural effusion cultures and declining serum cryptococcal antigen titers, the patient presented with progressive pulmonary infiltration, intermittent fever, and elevated C-reactive protein. Steroids were given for suspected IRIS, and the clinical condition improved dramatically. This is the first report on paradoxical cryptococcal IRIS in a patient with advanced CKD.

Original language	English
Pages (from-to)	1505-1509
Number of pages	5
Journal	International Urology and Nephrology
Volume	45
Issue number	5
DOIs	https://doi.org/10.1007/s11255-012-0196-y
Publication status	Published - Oct 1 2013
Externally published	Yes

Keywords

Chronic kidney disease
Cryptococcus
Immune reconstitution inflammatory syndrome

ASJC Scopus subject areas

Nephrology
Urology

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10.1007/s11255-012-0196-y

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title = "Paradoxical cryptococcal immune reconstitution inflammatory syndrome in advanced chronic kidney disease",

abstract = "Cryptococcal-related immune reconstitution inflammatory syndrome (IRIS) is frequently seen in immunocompromised patients. A 45-year-old man with advanced chronic kidney disease (CKD) received intensive antifungal treatment for pulmonary cryptococcosis. Despite negative pleural effusion cultures and declining serum cryptococcal antigen titers, the patient presented with progressive pulmonary infiltration, intermittent fever, and elevated C-reactive protein. Steroids were given for suspected IRIS, and the clinical condition improved dramatically. This is the first report on paradoxical cryptococcal IRIS in a patient with advanced CKD.",

keywords = "Chronic kidney disease, Cryptococcus, Immune reconstitution inflammatory syndrome",

author = "Kao, {Chih Chin} and Wu, {Vin Cent} and Sun, {Hsin Yun} and Wu, {Che Hsiung}",

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T1 - Paradoxical cryptococcal immune reconstitution inflammatory syndrome in advanced chronic kidney disease

AU - Kao, Chih Chin

AU - Wu, Vin Cent

AU - Sun, Hsin Yun

AU - Wu, Che Hsiung

PY - 2013/10/1

Y1 - 2013/10/1

N2 - Cryptococcal-related immune reconstitution inflammatory syndrome (IRIS) is frequently seen in immunocompromised patients. A 45-year-old man with advanced chronic kidney disease (CKD) received intensive antifungal treatment for pulmonary cryptococcosis. Despite negative pleural effusion cultures and declining serum cryptococcal antigen titers, the patient presented with progressive pulmonary infiltration, intermittent fever, and elevated C-reactive protein. Steroids were given for suspected IRIS, and the clinical condition improved dramatically. This is the first report on paradoxical cryptococcal IRIS in a patient with advanced CKD.

AB - Cryptococcal-related immune reconstitution inflammatory syndrome (IRIS) is frequently seen in immunocompromised patients. A 45-year-old man with advanced chronic kidney disease (CKD) received intensive antifungal treatment for pulmonary cryptococcosis. Despite negative pleural effusion cultures and declining serum cryptococcal antigen titers, the patient presented with progressive pulmonary infiltration, intermittent fever, and elevated C-reactive protein. Steroids were given for suspected IRIS, and the clinical condition improved dramatically. This is the first report on paradoxical cryptococcal IRIS in a patient with advanced CKD.

KW - Chronic kidney disease

KW - Cryptococcus

KW - Immune reconstitution inflammatory syndrome

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Paradoxical cryptococcal immune reconstitution inflammatory syndrome in advanced chronic kidney disease

Abstract

Keywords

ASJC Scopus subject areas

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