Papaverine and prostaglandin E1 gel applications for impotence

H. S. Chiang, Y. H. Kao, M. T. Sheu

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


The transdermal permeability of papaverine and prostaglandin E1 (PGE1) could be determined in vitro. A chemical scheme of passive delivery or with enhancer, as well as a physical iontophoretic transdermal delivery system were designed in the laboratory. Clinically, up to 20% papaverine base gel and 500 μg PGE1 were applied onto the genital area without any side effect. Only vascular response could be detected by ultrasound. However, immediate erection could not be obtained at the present dosage. Further research on the combination of skin absorption enhancers, the different chemical derivatives of PGE1 or a different administration route is warranted.

Original languageEnglish
Pages (from-to)767-769
Number of pages3
JournalAnnals of the Academy of Medicine Singapore
Issue number5
Publication statusPublished - 1995


  • erectile dysfunction
  • intracavernosal vasodilating agent
  • iontophoresis
  • male sexual therapy
  • transdermal delivery system

ASJC Scopus subject areas

  • Medicine(all)


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