P53R2 expression as a prognostic biomarker in early stage non-small cell lung cancer

Nan Yung Hsu; Jeng Yuan Wu; Xiyong Liu; Yun Yen; Chih Yi Chen; Ming Chih Chou; Huei Lee; Ya Wen Cheng

doi:10.3892/ol_00000108

P53R2 expression as a prognostic biomarker in early stage non-small cell lung cancer

Nan Yung Hsu, Jeng Yuan Wu, Xiyong Liu, Yun Yen, Chih Yi Chen, Ming Chih Chou, Huei Lee, Ya Wen Cheng

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

p53R2 is a small subunit of ribonucleotide reductase (RR) which has 80% homology to hRRM2 and metastasis suppressing potential. Previous reports suggested that the expression of p53R2 is used as a prognostic factor and chemo-therapy response indicator in several types of cancer. This study aimed to elucidate the association of p53R2 expression and the clinicopathological characteristics of early stage non small cell lung cancer (NSCLC). Immuno histochemistry was conducted on a tissue array including 92 early stage NSCLC samples. Correlations between p53R2 and clinicopathological factors, recurrence/metastasis and outcomes were analyzed. The analyses showed that there was no correlation between p53R2 expression and the clinicopathological factors. Among disease-free patients during follow-up, patients with p53R2(+) had a better outcome than those with p53R2(-) (P=0.022). By using Cox multivariate regression analysis, p53R2 (risk factor 3.801; 95% CI 1.004-9.454; P=0.044) served as a prognostic biomarker in the prediction of the survival rate for NSCLC patients. Detection of the RR subunit p53R2 may therefore be a useful prognostic marker in early stage NSCLC.

Original language	English
Pages (from-to)	609-613
Number of pages	5
Journal	Oncology Letters
Volume	1
Issue number	4
DOIs	https://doi.org/10.3892/ol_00000108
Publication status	Published - Jul 2010
Externally published	Yes

Keywords

Early stage
Non-small cell lung cancer
P53R2
Ribonucleotide reductase

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3892/ol_00000108

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title = "P53R2 expression as a prognostic biomarker in early stage non-small cell lung cancer",

abstract = "p53R2 is a small subunit of ribonucleotide reductase (RR) which has 80% homology to hRRM2 and metastasis suppressing potential. Previous reports suggested that the expression of p53R2 is used as a prognostic factor and chemo-therapy response indicator in several types of cancer. This study aimed to elucidate the association of p53R2 expression and the clinicopathological characteristics of early stage non small cell lung cancer (NSCLC). Immuno histochemistry was conducted on a tissue array including 92 early stage NSCLC samples. Correlations between p53R2 and clinicopathological factors, recurrence/metastasis and outcomes were analyzed. The analyses showed that there was no correlation between p53R2 expression and the clinicopathological factors. Among disease-free patients during follow-up, patients with p53R2(+) had a better outcome than those with p53R2(-) (P=0.022). By using Cox multivariate regression analysis, p53R2 (risk factor 3.801; 95% CI 1.004-9.454; P=0.044) served as a prognostic biomarker in the prediction of the survival rate for NSCLC patients. Detection of the RR subunit p53R2 may therefore be a useful prognostic marker in early stage NSCLC.",

keywords = "Early stage, Non-small cell lung cancer, P53R2, Ribonucleotide reductase",

author = "Hsu, {Nan Yung} and Wu, {Jeng Yuan} and Xiyong Liu and Yun Yen and Chen, {Chih Yi} and Chou, {Ming Chih} and Huei Lee and Cheng, {Ya Wen}",

year = "2010",

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doi = "10.3892/ol_00000108",

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T1 - P53R2 expression as a prognostic biomarker in early stage non-small cell lung cancer

AU - Hsu, Nan Yung

AU - Wu, Jeng Yuan

AU - Liu, Xiyong

AU - Yen, Yun

AU - Chen, Chih Yi

AU - Chou, Ming Chih

AU - Lee, Huei

AU - Cheng, Ya Wen

PY - 2010/7

Y1 - 2010/7

N2 - p53R2 is a small subunit of ribonucleotide reductase (RR) which has 80% homology to hRRM2 and metastasis suppressing potential. Previous reports suggested that the expression of p53R2 is used as a prognostic factor and chemo-therapy response indicator in several types of cancer. This study aimed to elucidate the association of p53R2 expression and the clinicopathological characteristics of early stage non small cell lung cancer (NSCLC). Immuno histochemistry was conducted on a tissue array including 92 early stage NSCLC samples. Correlations between p53R2 and clinicopathological factors, recurrence/metastasis and outcomes were analyzed. The analyses showed that there was no correlation between p53R2 expression and the clinicopathological factors. Among disease-free patients during follow-up, patients with p53R2(+) had a better outcome than those with p53R2(-) (P=0.022). By using Cox multivariate regression analysis, p53R2 (risk factor 3.801; 95% CI 1.004-9.454; P=0.044) served as a prognostic biomarker in the prediction of the survival rate for NSCLC patients. Detection of the RR subunit p53R2 may therefore be a useful prognostic marker in early stage NSCLC.

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KW - Non-small cell lung cancer

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KW - Ribonucleotide reductase

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P53R2 expression as a prognostic biomarker in early stage non-small cell lung cancer

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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