Oxidative stress change by systemic corticosteroid treatment among patients having active graves ophthalmopathy

Chieh Chih Tsai, Shu Ching Kao, Ching Yu Cheng, Hui Chuan Kau, Wen Ming Hsu, Cheng Feng Lee, Yau Huei Wei

Research output: Contribution to journalArticlepeer-review

51 Citations (Scopus)

Abstract

Objectives: To measure the 8-hydroxy-2′-deoxyguanosine (8-OHdG) level in patients having active Graves ophthalmopathy (GO) and to compare this oxidative stress biomarker and the clinical evolution of patients after systemic corticosteroid treatment. Methods: In 8 euthyroid patients having active GO, we determined the 8-OHdG levels in urine before, during, and after intensive corticosteroid therapy. Clinical activity and ophthalmopathy index scores were assessed. Nine age- and sex-matched healthy volunteers served as control subjects. Results: The mean 8-OHdG level was statistically significantly increased in patients having active GO compared with that of controls (17.47 vs 5.97 ng/mg of creatinine, P < .001). During and after maximal systemic corticosteroid treatment, patients had statistically significantly lower mean 8-OHdG levels (7.19 and 10.18 ng/mg of creatinine, respectively) compared with the mean level before treatment. These changes were accompanied by decreases in clinical activity and ophthalmopathy index scores. The urinary 8-OHdG levels were subsequently elevated in 2 patients having recurrent active GO when corticosteroid therapy was tapered or withdrawn. Conclusions: Oxidative stress may have a role in the pathogenesis of GO. Urinary 8-OHdG level can be used not only as a noninvasive biomarker of oxidative stress in patients having GO but also as an objective and quantitative parameter in the follow-up of patients during immunosuppressive treatment.

Original languageEnglish
Pages (from-to)1652-1656
Number of pages5
JournalArchives of Ophthalmology
Volume125
Issue number12
DOIs
Publication statusPublished - Dec 2007
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology

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