Overexpression of JAK2: A predictor of unfavorable prognosis for nasopharyngeal carcinoma

Hong Lin He; Ying En Lee; Peir In Liang; Sung Wei Lee; Tzu Ju Chen; Ti Chun Chan; Chung Hsi Hsing; I. Wei Chang; Yow Ling Shiue; Chien Feng Li

doi:10.2217/fon-2016-0025

Overexpression of JAK2: A predictor of unfavorable prognosis for nasopharyngeal carcinoma

Hong Lin He, Ying En Lee, Peir In Liang, Sung Wei Lee, Tzu Ju Chen, Ti Chun Chan, Chung Hsi Hsing, I. Wei Chang, Yow Ling Shiue, Chien Feng Li

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Purpose: Analysis of the nasopharyngeal carcinoma public transcriptome revealed JAK2 was significantly upregulated in tumors, which encouraged us to investigate its prognostic significance and mutational status. Materials & methods: We assessed the immune-expression of JAK2 and its relationships with various clinicopathological parameters. JAK2 mutation was detected by PCR followed by sequencing. Results: High expression of JAK2 was significantly associated with advanced tumor staging (p = 0.019). JAK2 overexpression acted as an independent predictor for worse disease-specific survival (p = 0.005), distant metastasis-free survival (p = 0.036), local recurrence-free survival (p = 0.012) and overall survival (p = 0.007). JAK2 mutation was not detected in selected cases with JAK2 protein overexpression. Conclusion: JAK2 can serve as a valuable negative prognostic factor and a potential therapeutic target.

Original language	English
Pages (from-to)	1887-1896
Number of pages	10
Journal	Future Oncology
Volume	12
Issue number	16
DOIs	https://doi.org/10.2217/fon-2016-0025
Publication status	Published - Aug 2016
Externally published	Yes

Keywords

JAK2
Janus kinase
nasopharyngeal carcinoma
prognosis
transcriptome

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2217/fon-2016-0025

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title = "Overexpression of JAK2: A predictor of unfavorable prognosis for nasopharyngeal carcinoma",

abstract = "Purpose: Analysis of the nasopharyngeal carcinoma public transcriptome revealed JAK2 was significantly upregulated in tumors, which encouraged us to investigate its prognostic significance and mutational status. Materials & methods: We assessed the immune-expression of JAK2 and its relationships with various clinicopathological parameters. JAK2 mutation was detected by PCR followed by sequencing. Results: High expression of JAK2 was significantly associated with advanced tumor staging (p = 0.019). JAK2 overexpression acted as an independent predictor for worse disease-specific survival (p = 0.005), distant metastasis-free survival (p = 0.036), local recurrence-free survival (p = 0.012) and overall survival (p = 0.007). JAK2 mutation was not detected in selected cases with JAK2 protein overexpression. Conclusion: JAK2 can serve as a valuable negative prognostic factor and a potential therapeutic target.",

keywords = "JAK2, Janus kinase, nasopharyngeal carcinoma, prognosis, transcriptome",

author = "He, {Hong Lin} and Lee, {Ying En} and Liang, {Peir In} and Lee, {Sung Wei} and Chen, {Tzu Ju} and Chan, {Ti Chun} and Hsing, {Chung Hsi} and Chang, {I. Wei} and Shiue, {Yow Ling} and Li, {Chien Feng}",

note = "Publisher Copyright: {\textcopyright} 2016 Future Medicine Ltd.",

year = "2016",

month = aug,

doi = "10.2217/fon-2016-0025",

language = "English",

volume = "12",

pages = "1887--1896",

journal = "Future Oncology",

issn = "1479-6694",

publisher = "Future Medicine Ltd.",

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TY - JOUR

T1 - Overexpression of JAK2

T2 - A predictor of unfavorable prognosis for nasopharyngeal carcinoma

AU - He, Hong Lin

AU - Lee, Ying En

AU - Liang, Peir In

AU - Lee, Sung Wei

AU - Chen, Tzu Ju

AU - Chan, Ti Chun

AU - Hsing, Chung Hsi

AU - Chang, I. Wei

AU - Shiue, Yow Ling

AU - Li, Chien Feng

PY - 2016/8

Y1 - 2016/8

N2 - Purpose: Analysis of the nasopharyngeal carcinoma public transcriptome revealed JAK2 was significantly upregulated in tumors, which encouraged us to investigate its prognostic significance and mutational status. Materials & methods: We assessed the immune-expression of JAK2 and its relationships with various clinicopathological parameters. JAK2 mutation was detected by PCR followed by sequencing. Results: High expression of JAK2 was significantly associated with advanced tumor staging (p = 0.019). JAK2 overexpression acted as an independent predictor for worse disease-specific survival (p = 0.005), distant metastasis-free survival (p = 0.036), local recurrence-free survival (p = 0.012) and overall survival (p = 0.007). JAK2 mutation was not detected in selected cases with JAK2 protein overexpression. Conclusion: JAK2 can serve as a valuable negative prognostic factor and a potential therapeutic target.

AB - Purpose: Analysis of the nasopharyngeal carcinoma public transcriptome revealed JAK2 was significantly upregulated in tumors, which encouraged us to investigate its prognostic significance and mutational status. Materials & methods: We assessed the immune-expression of JAK2 and its relationships with various clinicopathological parameters. JAK2 mutation was detected by PCR followed by sequencing. Results: High expression of JAK2 was significantly associated with advanced tumor staging (p = 0.019). JAK2 overexpression acted as an independent predictor for worse disease-specific survival (p = 0.005), distant metastasis-free survival (p = 0.036), local recurrence-free survival (p = 0.012) and overall survival (p = 0.007). JAK2 mutation was not detected in selected cases with JAK2 protein overexpression. Conclusion: JAK2 can serve as a valuable negative prognostic factor and a potential therapeutic target.

KW - JAK2

KW - Janus kinase

KW - nasopharyngeal carcinoma

KW - prognosis

KW - transcriptome

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U2 - 10.2217/fon-2016-0025

DO - 10.2217/fon-2016-0025

M3 - Article

C2 - 27086650

AN - SCOPUS:84979508776

SN - 1479-6694

VL - 12

SP - 1887

EP - 1896

JO - Future Oncology

JF - Future Oncology

IS - 16

ER -

Overexpression of JAK2: A predictor of unfavorable prognosis for nasopharyngeal carcinoma

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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