Overexpression of GRP78 is associated with malignant transformation in epithelial ovarian tumors

Lee Wen Huang; Ching Yu Lin; Chin Cheng Lee; Tsan Zon Liu; Cherng Jye Jeng

doi:10.1097/PAI.0b013e3182434113

Overexpression of GRP78 is associated with malignant transformation in epithelial ovarian tumors

Lee Wen Huang, Ching Yu Lin, Chin Cheng Lee, Tsan Zon Liu, Cherng Jye Jeng

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

AIM: Glucose-regulated protein 78 (GRP78) is one of the best-characterized endoplasmic reticulum chaperone proteins. The aim of this study was to explore the potential implications of GRP78 in the development of epithelial ovarian carcinomas (EOCs) and the possible clinical usefulness of GRP78 expression as a prognostic biomarker for EOCs. MATERIALS AND METHODS: A total of 133 women were enrolled. This pilot study consisted of 96 cases of EOCs and 37 cases of benign ovarian tumors as controls. The expression of GRP78 protein was studied using tissue microarray technology and immunohistochemistry. RESULTS: Of the 96 invasive carcinomas analyzed, 25 cases (26.0%) showed moderate GRP78 expression and 65 cases (67.7%) showed strong GRP78 expression. Conversely, 17 (45.9%) of the 37 patients with benign ovarian tumors showed no or weak GRP78 staining. Our results demonstrated that GRP78 expression was significantly higher in EOCs than in benign ovarian tumors (P

Original language	English
Pages (from-to)	381-385
Number of pages	5
Journal	Applied Immunohistochemistry and Molecular Morphology
Volume	20
Issue number	4
DOIs	https://doi.org/10.1097/PAI.0b013e3182434113
Publication status	Published - Jul 2012

Keywords

benign ovarian tumor
epithelial ovarian carcinoma
GRP78
immunohistochemistry

ASJC Scopus subject areas

Pathology and Forensic Medicine
Medical Laboratory Technology
Histology

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10.1097/PAI.0b013e3182434113

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title = "Overexpression of GRP78 is associated with malignant transformation in epithelial ovarian tumors",

abstract = "AIM: Glucose-regulated protein 78 (GRP78) is one of the best-characterized endoplasmic reticulum chaperone proteins. The aim of this study was to explore the potential implications of GRP78 in the development of epithelial ovarian carcinomas (EOCs) and the possible clinical usefulness of GRP78 expression as a prognostic biomarker for EOCs. MATERIALS AND METHODS: A total of 133 women were enrolled. This pilot study consisted of 96 cases of EOCs and 37 cases of benign ovarian tumors as controls. The expression of GRP78 protein was studied using tissue microarray technology and immunohistochemistry. RESULTS: Of the 96 invasive carcinomas analyzed, 25 cases (26.0%) showed moderate GRP78 expression and 65 cases (67.7%) showed strong GRP78 expression. Conversely, 17 (45.9%) of the 37 patients with benign ovarian tumors showed no or weak GRP78 staining. Our results demonstrated that GRP78 expression was significantly higher in EOCs than in benign ovarian tumors (P",

keywords = "benign ovarian tumor, epithelial ovarian carcinoma, GRP78, immunohistochemistry",

author = "Huang, {Lee Wen} and Lin, {Ching Yu} and Lee, {Chin Cheng} and Liu, {Tsan Zon} and Jeng, {Cherng Jye}",

year = "2012",

month = jul,

doi = "10.1097/PAI.0b013e3182434113",

language = "English",

volume = "20",

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journal = "Applied Immunohistochemistry and Molecular Morphology",

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T1 - Overexpression of GRP78 is associated with malignant transformation in epithelial ovarian tumors

AU - Huang, Lee Wen

AU - Lin, Ching Yu

AU - Lee, Chin Cheng

AU - Liu, Tsan Zon

AU - Jeng, Cherng Jye

PY - 2012/7

Y1 - 2012/7

N2 - AIM: Glucose-regulated protein 78 (GRP78) is one of the best-characterized endoplasmic reticulum chaperone proteins. The aim of this study was to explore the potential implications of GRP78 in the development of epithelial ovarian carcinomas (EOCs) and the possible clinical usefulness of GRP78 expression as a prognostic biomarker for EOCs. MATERIALS AND METHODS: A total of 133 women were enrolled. This pilot study consisted of 96 cases of EOCs and 37 cases of benign ovarian tumors as controls. The expression of GRP78 protein was studied using tissue microarray technology and immunohistochemistry. RESULTS: Of the 96 invasive carcinomas analyzed, 25 cases (26.0%) showed moderate GRP78 expression and 65 cases (67.7%) showed strong GRP78 expression. Conversely, 17 (45.9%) of the 37 patients with benign ovarian tumors showed no or weak GRP78 staining. Our results demonstrated that GRP78 expression was significantly higher in EOCs than in benign ovarian tumors (P

AB - AIM: Glucose-regulated protein 78 (GRP78) is one of the best-characterized endoplasmic reticulum chaperone proteins. The aim of this study was to explore the potential implications of GRP78 in the development of epithelial ovarian carcinomas (EOCs) and the possible clinical usefulness of GRP78 expression as a prognostic biomarker for EOCs. MATERIALS AND METHODS: A total of 133 women were enrolled. This pilot study consisted of 96 cases of EOCs and 37 cases of benign ovarian tumors as controls. The expression of GRP78 protein was studied using tissue microarray technology and immunohistochemistry. RESULTS: Of the 96 invasive carcinomas analyzed, 25 cases (26.0%) showed moderate GRP78 expression and 65 cases (67.7%) showed strong GRP78 expression. Conversely, 17 (45.9%) of the 37 patients with benign ovarian tumors showed no or weak GRP78 staining. Our results demonstrated that GRP78 expression was significantly higher in EOCs than in benign ovarian tumors (P

KW - benign ovarian tumor

KW - epithelial ovarian carcinoma

KW - GRP78

KW - immunohistochemistry

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Overexpression of GRP78 is associated with malignant transformation in epithelial ovarian tumors

Abstract

Keywords

ASJC Scopus subject areas

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