Outcomes of right-sided and left-sided colon cancer after curative resection

Chien Yi Yang; Min Hsuan Yen; Kee Thai Kiu; Yu Ting Chen; Tung Cheng Chang

doi:10.1038/s41598-022-15571-2

Outcomes of right-sided and left-sided colon cancer after curative resection

Chien Yi Yang, Min Hsuan Yen, Kee Thai Kiu, Yu Ting Chen, Tung Cheng Chang

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

The right and left side of the colon derived from the midgut and hindgut, respectively. Previous studies have reported different characteristics of right-sided colon cancer (RCC) and left-sided colon cancer (LCC), but oncological outcomes remain unclear. This study compared the outcomes of RCC and LCC. This retrospective study included 1017 patients who received curative colectomy for stage I-III colon cancer at a single institute between August 2008 and December 2019. Overall survival (OS) and time to recurrence (TTR) were analyzed as outcome measurements. No significant difference in the OS or TTR of patients with RCC and LCC were observed. In subgroup analysis, RCC was associated with shorter TTR than LCC in stage II colon cancer (HR 2.36, 95% confidence interval 1.24–4.48, p < 0.01). Multivariate analysis demonstrated that right sidedness, R1 resection, low body mass index (BMI) and adjuvant chemotherapy were independent factors for poor prognosis for stage II colon cancer. Low BMI, perineural invasion, higher T stage and N2 stage were independent factors for poor prognosis for stage III colon cancer. The results were confirmed by multivariate analysis after propensity score matching. Our study revealed that RCC was an independent risk factor for recurrence in stage II colon cancer.

Original language	English
Article number	11323
Journal	Scientific Reports
Volume	12
Issue number	1
DOIs	https://doi.org/10.1038/s41598-022-15571-2
Publication status	Published - Dec 2022

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title = "Outcomes of right-sided and left-sided colon cancer after curative resection",

abstract = "The right and left side of the colon derived from the midgut and hindgut, respectively. Previous studies have reported different characteristics of right-sided colon cancer (RCC) and left-sided colon cancer (LCC), but oncological outcomes remain unclear. This study compared the outcomes of RCC and LCC. This retrospective study included 1017 patients who received curative colectomy for stage I-III colon cancer at a single institute between August 2008 and December 2019. Overall survival (OS) and time to recurrence (TTR) were analyzed as outcome measurements. No significant difference in the OS or TTR of patients with RCC and LCC were observed. In subgroup analysis, RCC was associated with shorter TTR than LCC in stage II colon cancer (HR 2.36, 95% confidence interval 1.24–4.48, p < 0.01). Multivariate analysis demonstrated that right sidedness, R1 resection, low body mass index (BMI) and adjuvant chemotherapy were independent factors for poor prognosis for stage II colon cancer. Low BMI, perineural invasion, higher T stage and N2 stage were independent factors for poor prognosis for stage III colon cancer. The results were confirmed by multivariate analysis after propensity score matching. Our study revealed that RCC was an independent risk factor for recurrence in stage II colon cancer.",

author = "Yang, {Chien Yi} and Yen, {Min Hsuan} and Kiu, {Kee Thai} and Chen, {Yu Ting} and Chang, {Tung Cheng}",

note = "Funding Information: This manuscript was edited by Wallace Academic Editing. Publisher Copyright: {\textcopyright} 2022, The Author(s).",

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AU - Kiu, Kee Thai

AU - Chen, Yu Ting

AU - Chang, Tung Cheng

PY - 2022/12

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Outcomes of right-sided and left-sided colon cancer after curative resection

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