Osthole improves aspects of spatial performance in ovariectomized rats

Ming Tsuen Hsieh; Chia Ling Hsieh; Wen Hsin Wang; Chia Sheng Chen; Chun Ju Lin; Chi Rei Wu

doi:10.1142/S0192415X04001758

Osthole improves aspects of spatial performance in ovariectomized rats

Ming Tsuen Hsieh, Chia Ling Hsieh, Wen Hsin Wang, Chia Sheng Chen, Chun Ju Lin, Chi Rei Wu

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

The present study was designed to investigate the ameliorating effects of Cnidiuim monnieri L. Cusson (CM) and osthole, a constituent of CM, on the spatial performance deficit in scopolamine (SCOP)-treated or ovariectomized (OVA) rats. CM improved the deficit of spatial performance, and reversed the lower plasma estradiol levels caused by SCOP in female rats. In addition, osthole (3 and 10 mg/kg, sc) improved the performance deficit in OVA rats. It (10 and 30 μg/brain, icv) also improved the performance deficit caused by SCOP in intact female rats, and at 30 μg/brain improved the deficit in OVA rats. However, osthole did not alter the latency swum to reach the visible target in SCOP-treated and OVA rats. Accordingly, we suggested that osthole is an active constituent of CM, and possesses ameliorating effects on the spatial performance deficits in SCOP-treated female rats or OVA rats. The action mechanism of the effects of osthole on performance deficits was related to the estrogen-like properties and activating the central cholinergic neuronal system.

Original language	English
Pages (from-to)	11-20
Number of pages	10
Journal	American Journal of Chinese Medicine
Volume	32
Issue number	1
DOIs	https://doi.org/10.1142/S0192415X04001758
Publication status	Published - 2004
Externally published	Yes

Keywords

Cnidiuim monnieri
Osthole
Ovariectomized rats
Scopolamine
Spatial performance
Umbelliferae

ASJC Scopus subject areas

Complementary and alternative medicine

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10.1142/S0192415X04001758

Cite this

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title = "Osthole improves aspects of spatial performance in ovariectomized rats",

abstract = "The present study was designed to investigate the ameliorating effects of Cnidiuim monnieri L. Cusson (CM) and osthole, a constituent of CM, on the spatial performance deficit in scopolamine (SCOP)-treated or ovariectomized (OVA) rats. CM improved the deficit of spatial performance, and reversed the lower plasma estradiol levels caused by SCOP in female rats. In addition, osthole (3 and 10 mg/kg, sc) improved the performance deficit in OVA rats. It (10 and 30 μg/brain, icv) also improved the performance deficit caused by SCOP in intact female rats, and at 30 μg/brain improved the deficit in OVA rats. However, osthole did not alter the latency swum to reach the visible target in SCOP-treated and OVA rats. Accordingly, we suggested that osthole is an active constituent of CM, and possesses ameliorating effects on the spatial performance deficits in SCOP-treated female rats or OVA rats. The action mechanism of the effects of osthole on performance deficits was related to the estrogen-like properties and activating the central cholinergic neuronal system.",

keywords = "Cnidiuim monnieri, Osthole, Ovariectomized rats, Scopolamine, Spatial performance, Umbelliferae",

author = "Hsieh, {Ming Tsuen} and Hsieh, {Chia Ling} and Wang, {Wen Hsin} and Chen, {Chia Sheng} and Lin, {Chun Ju} and Wu, {Chi Rei}",

note = "Funding Information: We are thankful to the National Sciences Council for the financial support of this manuscript under Contract No. NSC89-2320-B-039-049, NSC90-2320-B-039-040, NSC89-2745-P-039-002 and NSC90-2745-P-039-002, and Chin Medical University CMC90-CPS-01, CMC90-CPS-05, CMU92-CPS-02 and CMU92-CPS-04.",

year = "2004",

doi = "10.1142/S0192415X04001758",

language = "English",

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AU - Hsieh, Ming Tsuen

AU - Hsieh, Chia Ling

AU - Wang, Wen Hsin

AU - Chen, Chia Sheng

AU - Lin, Chun Ju

AU - Wu, Chi Rei

N1 - Funding Information: We are thankful to the National Sciences Council for the financial support of this manuscript under Contract No. NSC89-2320-B-039-049, NSC90-2320-B-039-040, NSC89-2745-P-039-002 and NSC90-2745-P-039-002, and Chin Medical University CMC90-CPS-01, CMC90-CPS-05, CMU92-CPS-02 and CMU92-CPS-04.

PY - 2004

Y1 - 2004

N2 - The present study was designed to investigate the ameliorating effects of Cnidiuim monnieri L. Cusson (CM) and osthole, a constituent of CM, on the spatial performance deficit in scopolamine (SCOP)-treated or ovariectomized (OVA) rats. CM improved the deficit of spatial performance, and reversed the lower plasma estradiol levels caused by SCOP in female rats. In addition, osthole (3 and 10 mg/kg, sc) improved the performance deficit in OVA rats. It (10 and 30 μg/brain, icv) also improved the performance deficit caused by SCOP in intact female rats, and at 30 μg/brain improved the deficit in OVA rats. However, osthole did not alter the latency swum to reach the visible target in SCOP-treated and OVA rats. Accordingly, we suggested that osthole is an active constituent of CM, and possesses ameliorating effects on the spatial performance deficits in SCOP-treated female rats or OVA rats. The action mechanism of the effects of osthole on performance deficits was related to the estrogen-like properties and activating the central cholinergic neuronal system.

AB - The present study was designed to investigate the ameliorating effects of Cnidiuim monnieri L. Cusson (CM) and osthole, a constituent of CM, on the spatial performance deficit in scopolamine (SCOP)-treated or ovariectomized (OVA) rats. CM improved the deficit of spatial performance, and reversed the lower plasma estradiol levels caused by SCOP in female rats. In addition, osthole (3 and 10 mg/kg, sc) improved the performance deficit in OVA rats. It (10 and 30 μg/brain, icv) also improved the performance deficit caused by SCOP in intact female rats, and at 30 μg/brain improved the deficit in OVA rats. However, osthole did not alter the latency swum to reach the visible target in SCOP-treated and OVA rats. Accordingly, we suggested that osthole is an active constituent of CM, and possesses ameliorating effects on the spatial performance deficits in SCOP-treated female rats or OVA rats. The action mechanism of the effects of osthole on performance deficits was related to the estrogen-like properties and activating the central cholinergic neuronal system.

KW - Cnidiuim monnieri

KW - Osthole

KW - Ovariectomized rats

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KW - Spatial performance

KW - Umbelliferae

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Osthole improves aspects of spatial performance in ovariectomized rats

Abstract

Keywords

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