Osteoporosis is associated with antiepileptic drugs: A population-based study

Fang Jen Wu; Shiow Yunn Sheu; Herng Ching Lin

doi:10.1684/epd.2014.0673

Osteoporosis is associated with antiepileptic drugs: A population-based study

Fang Jen Wu, Shiow Yunn Sheu, Herng Ching Lin

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

Controversy remains regarding the risk of bone abnormalities due to enzyme-inducing antiepileptic drugs (EIAEDs) and non-enzyme-inducing antiepileptic drugs (NEIAEDs). This case-control study aimed to investigate the possible association between osteoporosis and epilepsy disease and AEDs therapy using a population-based dataset in Taiwan. We first identified 48,102 cases, =18 years of age, who received a first-time diagnosis of osteoporosis, and then randomly selected 144,306 controls. We used conditional logistic regression analyses to compute the odds ratio (OR) and corresponding 95% confidence interval (CI) to compare a previous diagnosis of epilepsy between cases and controls. We found that of the 192,408 sampled subjects, epilepsy was found in 117 (0.24%) cases and 240 (0.17%) controls (p

Original language	English
Pages (from-to)	333-342
Number of pages	10
Journal	Epileptic Disorders
Volume	16
Issue number	3
DOIs	https://doi.org/10.1684/epd.2014.0673
Publication status	Published - Sept 1 2014

Keywords

Antiepileptic drug
Epilepsy
Osteoporosis

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1684/epd.2014.0673

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abstract = "Controversy remains regarding the risk of bone abnormalities due to enzyme-inducing antiepileptic drugs (EIAEDs) and non-enzyme-inducing antiepileptic drugs (NEIAEDs). This case-control study aimed to investigate the possible association between osteoporosis and epilepsy disease and AEDs therapy using a population-based dataset in Taiwan. We first identified 48,102 cases, =18 years of age, who received a first-time diagnosis of osteoporosis, and then randomly selected 144,306 controls. We used conditional logistic regression analyses to compute the odds ratio (OR) and corresponding 95% confidence interval (CI) to compare a previous diagnosis of epilepsy between cases and controls. We found that of the 192,408 sampled subjects, epilepsy was found in 117 (0.24%) cases and 240 (0.17%) controls (p",

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Osteoporosis is associated with antiepileptic drugs: A population-based study

Abstract

Keywords

ASJC Scopus subject areas

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