Controversy remains regarding the risk of bone abnormalities due to enzyme-inducing antiepileptic drugs (EIAEDs) and non-enzyme-inducing antiepileptic drugs (NEIAEDs). This case-control study aimed to investigate the possible association between osteoporosis and epilepsy disease and AEDs therapy using a population-based dataset in Taiwan. We first identified 48,102 cases, =18 years of age, who received a first-time diagnosis of osteoporosis, and then randomly selected 144,306 controls. We used conditional logistic regression analyses to compute the odds ratio (OR) and corresponding 95% confidence interval (CI) to compare a previous diagnosis of epilepsy between cases and controls. We found that of the 192,408 sampled subjects, epilepsy was found in 117 (0.24%) cases and 240 (0.17%) controls (p

Original languageEnglish
Pages (from-to)333-342
Number of pages10
JournalEpileptic Disorders
Issue number3
Publication statusPublished - Sept 1 2014


  • Antiepileptic drug
  • Epilepsy
  • Osteoporosis

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology


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