Osteopontin expression is a valuable marker for prediction of short-term recurrence in WHO grade I benign meningiomas

Kuan Yin Tseng, Min Huey Chung, Huey Kang Sytwu, Horng Mo Lee, Kuan Yu Chen, Chen Chang, Chih Kung Lin, Che Hung Yen, Jia Hong Chen, Gu Jiun Lin, Hsin I. Ma, Yi-Shian Yeh, Da Tong Ju, Ming Ying Liu, Dueng Yuan Hueng

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)


Prediction of recurrence remains a challenge in histopathological benign/grade I tumors. Osteopontin (OPN) plays important roles in tumorigenesis, invasion, and metastasis of several human cancers. In this study, we investigated OPN protein expression by evaluating the differences between recurrent and non-recurrent histologically benign meningiomas. Thirty-two patients were enrolled, and 23 benign non-recurrent meningiomas and 9 benign recurrent meningiomas were followed for a mean of 34 months after complete surgical resection (Simpson grades I and II). Cytoplasmic OPN staining was evaluated by means of immunohistochemistry (IHC) score and by use of the Allred-8-unit system. We examined clinical biological data, their relationship with tumor recurrence, and the expression of OPN. Our results showed that meningioma recurrence correlated significantly with OPN IHC score (P = 0.001). An OPN Allred score between 0 and 3 was associated with a recurrence-free time of more than 25 months. In comparison, an OPN Allred score from 4 to 8 was indicative of a shorter average recurrence-free time. We concluded that OPN IHC score may play a role in prediction of the recurrence of the grade I meningiomas. Moreover, determination of the OPN Allred score is a reliable, quantitative tool for predicting recurrence-free time in benign meningioma patients.

Original languageEnglish
Pages (from-to)217-223
Number of pages7
JournalJournal of Neuro-Oncology
Issue number2
Publication statusPublished - Nov 2010


  • Allred score
  • Immunohistochemical staining
  • Meningioma
  • Osteopontin
  • Recurrence

ASJC Scopus subject areas

  • Oncology
  • Neurology
  • Clinical Neurology
  • Cancer Research


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