Osteoblast and Osteoclast Activity in a Malignant Infantile Osteopetrosis Patient Following Bone Marrow Transplantation

Chun Jung Chen; Tsu Yi Chao; Der Ming Chu; Anthony J. Janckila; Shin Nan Cheng

doi:10.1097/00043426-200401000-00003

Osteoblast and Osteoclast Activity in a Malignant Infantile Osteopetrosis Patient Following Bone Marrow Transplantation

Chun Jung Chen, Tsu Yi Chao, Der Ming Chu, Anthony J. Janckila, Shin Nan Cheng

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

The authors treated a 6-month-old boy with malignant infantile osteopetrosis using bone marrow transplantation. The patient's clinical response was compared with his biochemical response for bone metabolic markers such as tartrate-resistant acid phosphatase 5b (TRAcP 5b) and bone-specific alkaline phosphatase (BAP). Treatment was successful, resulting in a decrease in the serum TRAcP 5b level. These bone-specific markers may be useful for the early assessment of malignant infantile osteopetrosis patients with stem cell transplantation.

Original language	English
Pages (from-to)	5-8
Number of pages	4
Journal	Journal of Pediatric Hematology/Oncology
Volume	26
Issue number	1
DOIs	https://doi.org/10.1097/00043426-200401000-00003
Publication status	Published - Jan 2004
Externally published	Yes

Keywords

Bone marrow transplantation
Bone-specific alkaline phosphatase
Children
Malignant infantile osteopetrosis
Tartrate-resistant acid phosphatase 5b

ASJC Scopus subject areas

Hematology
Oncology
Pediatrics, Perinatology, and Child Health

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10.1097/00043426-200401000-00003

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abstract = "The authors treated a 6-month-old boy with malignant infantile osteopetrosis using bone marrow transplantation. The patient's clinical response was compared with his biochemical response for bone metabolic markers such as tartrate-resistant acid phosphatase 5b (TRAcP 5b) and bone-specific alkaline phosphatase (BAP). Treatment was successful, resulting in a decrease in the serum TRAcP 5b level. These bone-specific markers may be useful for the early assessment of malignant infantile osteopetrosis patients with stem cell transplantation.",

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AU - Chao, Tsu Yi

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AU - Janckila, Anthony J.

AU - Cheng, Shin Nan

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AB - The authors treated a 6-month-old boy with malignant infantile osteopetrosis using bone marrow transplantation. The patient's clinical response was compared with his biochemical response for bone metabolic markers such as tartrate-resistant acid phosphatase 5b (TRAcP 5b) and bone-specific alkaline phosphatase (BAP). Treatment was successful, resulting in a decrease in the serum TRAcP 5b level. These bone-specific markers may be useful for the early assessment of malignant infantile osteopetrosis patients with stem cell transplantation.

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KW - Tartrate-resistant acid phosphatase 5b

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Osteoblast and Osteoclast Activity in a Malignant Infantile Osteopetrosis Patient Following Bone Marrow Transplantation

Abstract

Keywords

ASJC Scopus subject areas

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