Oseto tissue regeneration on Poly-ε-caprolactone with biomedical ceramic materials

3D porous biodegradable polymer scaffolds have been used for tissue engineering of bone repair or regeneration. The primary function of scaffolds is to provide structure support for the cells adhesion and proliferation. This study uses the Poly-ε-caprolactone (PCL) as material, NaCl mixed with hydroxyapatite (HA). This study uses the solution casting/particulate leaching method to fabricate the porous scaffold. This study discusses the compression mechanical properties, physical properties (porosity, moisture content, contact angle) of a pure PCL, PCL/mHA and PCL/nHA scaffolds. The in vitro cell culture is used for osteoblast cell (MG63) and the microculture tetrazolium test (MTT) is undertaken in the scaffold. The scaffolds are implanted to the femur of rats and histological examination is attempted after 2 weeks. The experimental results indicate that HA can improve the hydrophilic property. In conclusion, the PCL/nHA scaffold exhibits splendid in vivo biocompatibility and osteogenesis.