Orexins: A role in medullary sympathetic outflow

Nae J. Dun, Siok Le Dun,, Chiung Tong Chen, Ling Ling Hwang, Ernest H. Kwok, Jaw Kang Chang

Research output: Contribution to journalReview articlepeer-review

83 Citations (Scopus)


Orexin A and B, also known as hypocretin 1 and 2, are two recently isolated hypothalamic peptides. As orexin-containing neurons are strategically located in the lateral hypothalamus, which has long been suspected to play an important role in feeding behaviors, initial studies were focused on the involvement of orexins in positive food intake and energy metabolism. Recent studies implicate a more diverse biological role of orexins, which can be manifested at different level of the neuraxis. For example, canine narcolepsy, a disorder with close phenotypic similarity to human narcolepsy, is caused by a mutation of hypocretin receptor 2 gene. Results from our immunohistochemical and functional studies, which will be summarized here, suggest that the peptide acting on neurons in the rostral ventrolateral medulla augment sympathoexcitatory outflow to the spinal cord. This finding is discussed in the context of increased sympathetic activity frequently associated with obesity. Copyright (C) 2000 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)65-70
Number of pages6
JournalRegulatory Peptides
Issue number1-2
Publication statusPublished - Dec 22 2000


  • Fos
  • Hypertension
  • Medulla
  • Obesity
  • Rostral ventrolateral medulla
  • Sympathetic preganglionic neurons

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Clinical Biochemistry
  • Cellular and Molecular Neuroscience


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