Orally administered resveratrol enhances the therapeutic effect of autologous transplanted adipose-derived stem cells on rats with diabetic hepatopathy

T. S. Chen; C. H. Lai; C. Y. Shen; P. Y. Pai; R. J. Chen; V. PadmaViswanadha; C. K. Yang; M. C. Chen; Y. M. Lin; C. Y. Huang

doi:10.1080/10520295.2019.1631481

Orally administered resveratrol enhances the therapeutic effect of autologous transplanted adipose-derived stem cells on rats with diabetic hepatopathy

T. S. Chen, C. H. Lai, C. Y. Shen, P. Y. Pai, R. J. Chen, V. PadmaViswanadha, C. K. Yang, M. C. Chen, Y. M. Lin, C. Y. Huang

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Stem cell therapy is a promising treatment for hepatopathy due to diabetes mellitus (DM); oral resveratrol treatment exhibits protective effects. We investigated whether protective effects could be produced in liver of diabetic rats receiving autologous adipose-derived stem cell transplantation (ADSC) plus oral resveratrol administration. Male rats were divided into four groups: sham group; streptozotocin induced DM group; DM + ADSC group, in which DM rats were treated with 10⁶ stem cells/rat; and DM + R + ADSC group, in which DM rats were treated with ADSC and oral resveratrol. The DM group exhibited apoptosis, inflammation and fibrosis, whereas Sirt-1 and survival signaling were suppressed. Pathological conditions other than survival signaling were improved in the DM + ADSC group. All pathological conditions were improved in the DM + R + ADSC group. Also, the oxidative stress level in the blood was reduced in the DM + R + ADSC group compared to the sham group. Oral resveratrol administration appears to reduce oxidative damage and enhances survival signaling in diabetic liver. The therapeutic response in the DM + R + ADSC group was better than in the DM + ADSC group.

Original language	English
Pages (from-to)	37-45
Number of pages	9
Journal	Biotechnic and Histochemistry
Volume	95
Issue number	1
DOIs	https://doi.org/10.1080/10520295.2019.1631481
Publication status	Published - Jan 2 2020

Keywords

Adipose-derived stem cells
diabetes
hepatopathy
liver
resveratrol
transplantation

ASJC Scopus subject areas

Histology
Medical Laboratory Technology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/10520295.2019.1631481

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Chen, T. S., Lai, C. H., Shen, C. Y., Pai, P. Y., Chen, R. J., PadmaViswanadha, V., Yang, C. K., Chen, M. C., Lin, Y. M., & Huang, C. Y. (2020). Orally administered resveratrol enhances the therapeutic effect of autologous transplanted adipose-derived stem cells on rats with diabetic hepatopathy. Biotechnic and Histochemistry, 95(1), 37-45. https://doi.org/10.1080/10520295.2019.1631481

Chen, TS, Lai, CH, Shen, CY, Pai, PY, Chen, RJ, PadmaViswanadha, V, Yang, CK, Chen, MC, Lin, YM & Huang, CY 2020, 'Orally administered resveratrol enhances the therapeutic effect of autologous transplanted adipose-derived stem cells on rats with diabetic hepatopathy', Biotechnic and Histochemistry, vol. 95, no. 1, pp. 37-45. https://doi.org/10.1080/10520295.2019.1631481

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abstract = "Stem cell therapy is a promising treatment for hepatopathy due to diabetes mellitus (DM); oral resveratrol treatment exhibits protective effects. We investigated whether protective effects could be produced in liver of diabetic rats receiving autologous adipose-derived stem cell transplantation (ADSC) plus oral resveratrol administration. Male rats were divided into four groups: sham group; streptozotocin induced DM group; DM + ADSC group, in which DM rats were treated with 106 stem cells/rat; and DM + R + ADSC group, in which DM rats were treated with ADSC and oral resveratrol. The DM group exhibited apoptosis, inflammation and fibrosis, whereas Sirt-1 and survival signaling were suppressed. Pathological conditions other than survival signaling were improved in the DM + ADSC group. All pathological conditions were improved in the DM + R + ADSC group. Also, the oxidative stress level in the blood was reduced in the DM + R + ADSC group compared to the sham group. Oral resveratrol administration appears to reduce oxidative damage and enhances survival signaling in diabetic liver. The therapeutic response in the DM + R + ADSC group was better than in the DM + ADSC group.",

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author = "Chen, {T. S.} and Lai, {C. H.} and Shen, {C. Y.} and Pai, {P. Y.} and Chen, {R. J.} and V. PadmaViswanadha and Yang, {C. K.} and Chen, {M. C.} and Lin, {Y. M.} and Huang, {C. Y.}",

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AU - Chen, T. S.

AU - Lai, C. H.

AU - Shen, C. Y.

AU - Pai, P. Y.

AU - Chen, R. J.

AU - PadmaViswanadha, V.

AU - Yang, C. K.

AU - Chen, M. C.

AU - Lin, Y. M.

AU - Huang, C. Y.

N1 - Funding Information: Financial support for our work was provided by China Medical University Taiwan [CMU104-S-39] and Asia University Taiwan [CMU103-ASIA-13]. Publisher Copyright: © 2020, © 2020 The Biological Stain Commission.

PY - 2020/1/2

Y1 - 2020/1/2

N2 - Stem cell therapy is a promising treatment for hepatopathy due to diabetes mellitus (DM); oral resveratrol treatment exhibits protective effects. We investigated whether protective effects could be produced in liver of diabetic rats receiving autologous adipose-derived stem cell transplantation (ADSC) plus oral resveratrol administration. Male rats were divided into four groups: sham group; streptozotocin induced DM group; DM + ADSC group, in which DM rats were treated with 106 stem cells/rat; and DM + R + ADSC group, in which DM rats were treated with ADSC and oral resveratrol. The DM group exhibited apoptosis, inflammation and fibrosis, whereas Sirt-1 and survival signaling were suppressed. Pathological conditions other than survival signaling were improved in the DM + ADSC group. All pathological conditions were improved in the DM + R + ADSC group. Also, the oxidative stress level in the blood was reduced in the DM + R + ADSC group compared to the sham group. Oral resveratrol administration appears to reduce oxidative damage and enhances survival signaling in diabetic liver. The therapeutic response in the DM + R + ADSC group was better than in the DM + ADSC group.

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KW - hepatopathy

KW - liver

KW - resveratrol

KW - transplantation

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Orally administered resveratrol enhances the therapeutic effect of autologous transplanted adipose-derived stem cells on rats with diabetic hepatopathy

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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