Oral traumatic ulcerative granuloma with stromal eosinophilia: A clinicopathological study of 34 cases

Wei Ren Shen, Julia Yu Fong Chang, Yang Che Wu, Shih Jung Cheng, Hsin Ming Chen, Yi Ping Wang

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26 Citations (Scopus)


Background/Purpose: Traumatic ulcerative granuloma with stromal eosinophilia (TUGSE) is a special oral ulcerative lesion that shares many clinical features of an oral squamous cell carcinoma. This study reports the clinicopathological features of 34 oral TUGSE lesions in Taiwanese patients. Methods: Thirty-four TUGSE cases were retrieved from the files of the Department of Oral Pathology and Oral Diagnosis, National Taiwan University Hospital from 2003 to 2009. Their clinical data and histopathological features were examined, collected, and analyzed. Results: The study group included 22 male and 12 female patients (64.7% and 35.3%, respectively) with oral TUGSE. The mean age of the patients was 49 years (range, 8 to 80 years). The most common site for oral TUGSE lesions was the tongue (23 cases, 67.6%), followed by the buccal mucosa (6 cases, 17.6%), retromolar area (2 cases, 5.9%), floor of the mouth and lingual sulcus (2 cases, 5.9%), and lip (1 case, 3.0%). For 23 tongue cases, 19 occurred on the dorsum and the tip (82.6%) and 4 on the ventral surface (17.4%). Of the 34 oral TUGSE lesions, 13 (38.2%) had a mild, 11 (32.4%) a moderate, and 10 (29.4%) a severe eosinophilic infiltrate. Conclusion: Oral TUGSE lesions occur more frequently on the dorsal surface and the tip of the tongue and in male patients between 41 and 60 years of age. The eosinophilic infiltrates in oral TUGSE lesions show a scattered or clustered pattern, and their density varies from case to case. Oral TUGSE is a self-limiting lesion, and aggressive surgical treatment is usually not required.

Original languageEnglish
Pages (from-to)881-885
Number of pages5
JournalJournal of the Formosan Medical Association
Issue number9
Publication statusPublished - Sept 1 2015
Externally publishedYes


  • Clinical feature
  • Histopathological feature
  • Oral cavity
  • Traumatic ulcerative granuloma with stromal eosinophilia

ASJC Scopus subject areas

  • General Medicine


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