Oral submucous fibrosis: An update on pathophysiology of malignant transformation

Gururaj Arakeri; Shekar Gowda Patil; Abdulsalam S. Aljabab; Kuan Chou Lin; M. A.W. Merkx; Shan Gao; Peter A. Brennan

doi:10.1111/jop.12582

Oral submucous fibrosis: An update on pathophysiology of malignant transformation

Gururaj Arakeri, Shekar Gowda Patil, Abdulsalam S. Aljabab, Kuan Chou Lin, M. A.W. Merkx, Shan Gao, Peter A. Brennan

Research output: Contribution to journal › Review article › peer-review

47 Citations (Scopus)

Abstract

Oral submucous fibrosis (OSMF) is a potentially malignant condition associated with areca nut chewing. Formerly confined to the Indian subcontinent, it is now often seen in Asian populations of the United Kingdom, USA and other developed countries, and is therefore a serious problem for global health. What makes it more sinister is the malignant transformation rate, which has been reported to be around 7.6% over a 17-year period. In this concise article, we review the current trends in the pathophysiology of malignant transformation of OSMF.

Original language	English
Pages (from-to)	413-417
Number of pages	5
Journal	Journal of Oral Pathology and Medicine
Volume	46
Issue number	6
DOIs	https://doi.org/10.1111/jop.12582
Publication status	Published - Jul 2017

Keywords

malignant transformation
oral submucous fibrosis
review
squamous cell carcinoma

ASJC Scopus subject areas

Pathology and Forensic Medicine
Oral Surgery
Otorhinolaryngology
Cancer Research
Periodontics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/jop.12582

Cite this

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title = "Oral submucous fibrosis: An update on pathophysiology of malignant transformation",

abstract = "Oral submucous fibrosis (OSMF) is a potentially malignant condition associated with areca nut chewing. Formerly confined to the Indian subcontinent, it is now often seen in Asian populations of the United Kingdom, USA and other developed countries, and is therefore a serious problem for global health. What makes it more sinister is the malignant transformation rate, which has been reported to be around 7.6% over a 17-year period. In this concise article, we review the current trends in the pathophysiology of malignant transformation of OSMF.",

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T2 - An update on pathophysiology of malignant transformation

AU - Arakeri, Gururaj

AU - Patil, Shekar Gowda

AU - Aljabab, Abdulsalam S.

AU - Lin, Kuan Chou

AU - Merkx, M. A.W.

AU - Gao, Shan

AU - Brennan, Peter A.

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AB - Oral submucous fibrosis (OSMF) is a potentially malignant condition associated with areca nut chewing. Formerly confined to the Indian subcontinent, it is now often seen in Asian populations of the United Kingdom, USA and other developed countries, and is therefore a serious problem for global health. What makes it more sinister is the malignant transformation rate, which has been reported to be around 7.6% over a 17-year period. In this concise article, we review the current trends in the pathophysiology of malignant transformation of OSMF.

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KW - oral submucous fibrosis

KW - review

KW - squamous cell carcinoma

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Oral submucous fibrosis: An update on pathophysiology of malignant transformation

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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