Oral submucous fibrosis: An update on pathophysiology of malignant transformation

Gururaj Arakeri, Shekar Gowda Patil, Abdulsalam S. Aljabab, Kuan Chou Lin, M. A.W. Merkx, Shan Gao, Peter A. Brennan

Research output: Contribution to journalReview articlepeer-review

39 Citations (Scopus)


Oral submucous fibrosis (OSMF) is a potentially malignant condition associated with areca nut chewing. Formerly confined to the Indian subcontinent, it is now often seen in Asian populations of the United Kingdom, USA and other developed countries, and is therefore a serious problem for global health. What makes it more sinister is the malignant transformation rate, which has been reported to be around 7.6% over a 17-year period. In this concise article, we review the current trends in the pathophysiology of malignant transformation of OSMF.

Original languageEnglish
Pages (from-to)413-417
Number of pages5
JournalJournal of Oral Pathology and Medicine
Issue number6
Publication statusPublished - Jul 2017


  • malignant transformation
  • oral submucous fibrosis
  • review
  • squamous cell carcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Oral Surgery
  • Otorhinolaryngology
  • Cancer Research
  • Periodontics


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