Oral hygiene and the overall survival of head and neck cancer patients

Chan Chi Chang; Wei Ting Lee; Jenn Ren Hsiao; Chun Yen Ou; Cheng Chih Huang; Sen Tien Tsai; Ken Chung Chen; Jehn Shyun Huang; Tung Yiu Wong; Yu Hsuan Lai; Yuan Hua Wu; Wei Ting Hsueh; Shang Yin Wu; Chia Jui Yen; Jang Yang Chang; Chen Lin Lin; Ya Ling Weng; Han Chien Yang; Yu Shan Chen; Jeffrey S. Chang

doi:10.1002/cam4.2059

Oral hygiene and the overall survival of head and neck cancer patients

Chan Chi Chang, Wei Ting Lee, Jenn Ren Hsiao, Chun Yen Ou, Cheng Chih Huang, Sen Tien Tsai, Ken Chung Chen, Jehn Shyun Huang, Tung Yiu Wong, Yu Hsuan Lai, Yuan Hua Wu, Wei Ting Hsueh, Shang Yin Wu, Chia Jui Yen, Jang Yang Chang, Chen Lin Lin, Ya Ling Weng, Han Chien Yang, Yu Shan Chen, Jeffrey S. Chang

Research output: Contribution to journal › Article › peer-review

39 Citations (Scopus)

Abstract

Poor oral hygiene is an established risk factor of head and neck cancer (HNC); however, its role in the survival of HNC patients is unclear. This study evaluated the association between oral hygiene habits, including regular dental visits, frequency of tooth brushing, and use of dental floss, and the overall survival (OS) of HNC patients using interview data collected from 740 HNC patients. In addition, the interactions between oral hygiene and the polymorphisms of TLR2 and TLR4 on the OS of HNC patients were assessed. The analysis indicated that poor oral hygiene was significantly associated with poorer OS of HNC patients (hazard ratio (HR) = 1.38, 95% confidence interval (CI): 1.03-1.86). This association was modified by a single nucleotide polymorphism, rs11536889, of TLR4. A significant association between poor oral hygiene and worse survival of HNC was observed among those with the CG or CC genotype (HR = 2.32, 95% CI: 1.41-3.82) but not among those with the GG genotype (HR = 0.95, 95% CI: 0.65-1.40). Our results suggested that poor oral hygiene is not only a risk factor but may also be a prognostic factor of HNC.

Original language	English
Pages (from-to)	1854-1864
Number of pages	11
Journal	Cancer Medicine
Volume	8
Issue number	4
DOIs	https://doi.org/10.1002/cam4.2059
Publication status	Published - Apr 2019
Externally published	Yes

Keywords

epidemiology and prevention
gene–environmental interaction
head and neck cancer
survival

ASJC Scopus subject areas

Oncology
Radiology Nuclear Medicine and imaging
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/cam4.2059

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Chang, C. C., Lee, W. T., Hsiao, J. R., Ou, C. Y., Huang, C. C., Tsai, S. T., Chen, K. C., Huang, J. S., Wong, T. Y., Lai, Y. H., Wu, Y. H., Hsueh, W. T., Wu, S. Y., Yen, C. J., Chang, J. Y., Lin, C. L., Weng, Y. L., Yang, H. C., Chen, Y. S., & Chang, J. S. (2019). Oral hygiene and the overall survival of head and neck cancer patients. Cancer Medicine, 8(4), 1854-1864. https://doi.org/10.1002/cam4.2059

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title = "Oral hygiene and the overall survival of head and neck cancer patients",

abstract = "Poor oral hygiene is an established risk factor of head and neck cancer (HNC); however, its role in the survival of HNC patients is unclear. This study evaluated the association between oral hygiene habits, including regular dental visits, frequency of tooth brushing, and use of dental floss, and the overall survival (OS) of HNC patients using interview data collected from 740 HNC patients. In addition, the interactions between oral hygiene and the polymorphisms of TLR2 and TLR4 on the OS of HNC patients were assessed. The analysis indicated that poor oral hygiene was significantly associated with poorer OS of HNC patients (hazard ratio (HR) = 1.38, 95% confidence interval (CI): 1.03-1.86). This association was modified by a single nucleotide polymorphism, rs11536889, of TLR4. A significant association between poor oral hygiene and worse survival of HNC was observed among those with the CG or CC genotype (HR = 2.32, 95% CI: 1.41-3.82) but not among those with the GG genotype (HR = 0.95, 95% CI: 0.65-1.40). Our results suggested that poor oral hygiene is not only a risk factor but may also be a prognostic factor of HNC.",

keywords = "epidemiology and prevention, gene–environmental interaction, head and neck cancer, survival",

author = "Chang, {Chan Chi} and Lee, {Wei Ting} and Hsiao, {Jenn Ren} and Ou, {Chun Yen} and Huang, {Cheng Chih} and Tsai, {Sen Tien} and Chen, {Ken Chung} and Huang, {Jehn Shyun} and Wong, {Tung Yiu} and Lai, {Yu Hsuan} and Wu, {Yuan Hua} and Hsueh, {Wei Ting} and Wu, {Shang Yin} and Yen, {Chia Jui} and Chang, {Jang Yang} and Lin, {Chen Lin} and Weng, {Ya Ling} and Yang, {Han Chien} and Chen, {Yu Shan} and Chang, {Jeffrey S.}",

note = "Funding Information: This work was supported by grants from the Ministry of Science and Technology, Taiwan (105-2314-B-400-022), the National Health Research Institutes (CA-108-PP-01), and the Next-generation Pathway of Taiwan Cancer Precision Medicine Program (TCPMP) (AS-KPQ-107-TCPMP). Publisher Copyright: {\textcopyright} 2019 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.",

year = "2019",

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doi = "10.1002/cam4.2059",

language = "English",

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T1 - Oral hygiene and the overall survival of head and neck cancer patients

AU - Chang, Chan Chi

AU - Lee, Wei Ting

AU - Hsiao, Jenn Ren

AU - Ou, Chun Yen

AU - Huang, Cheng Chih

AU - Tsai, Sen Tien

AU - Chen, Ken Chung

AU - Huang, Jehn Shyun

AU - Wong, Tung Yiu

AU - Lai, Yu Hsuan

AU - Wu, Yuan Hua

AU - Hsueh, Wei Ting

AU - Wu, Shang Yin

AU - Yen, Chia Jui

AU - Chang, Jang Yang

AU - Lin, Chen Lin

AU - Weng, Ya Ling

AU - Yang, Han Chien

AU - Chen, Yu Shan

AU - Chang, Jeffrey S.

N1 - Funding Information: This work was supported by grants from the Ministry of Science and Technology, Taiwan (105-2314-B-400-022), the National Health Research Institutes (CA-108-PP-01), and the Next-generation Pathway of Taiwan Cancer Precision Medicine Program (TCPMP) (AS-KPQ-107-TCPMP). Publisher Copyright: © 2019 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

PY - 2019/4

Y1 - 2019/4

N2 - Poor oral hygiene is an established risk factor of head and neck cancer (HNC); however, its role in the survival of HNC patients is unclear. This study evaluated the association between oral hygiene habits, including regular dental visits, frequency of tooth brushing, and use of dental floss, and the overall survival (OS) of HNC patients using interview data collected from 740 HNC patients. In addition, the interactions between oral hygiene and the polymorphisms of TLR2 and TLR4 on the OS of HNC patients were assessed. The analysis indicated that poor oral hygiene was significantly associated with poorer OS of HNC patients (hazard ratio (HR) = 1.38, 95% confidence interval (CI): 1.03-1.86). This association was modified by a single nucleotide polymorphism, rs11536889, of TLR4. A significant association between poor oral hygiene and worse survival of HNC was observed among those with the CG or CC genotype (HR = 2.32, 95% CI: 1.41-3.82) but not among those with the GG genotype (HR = 0.95, 95% CI: 0.65-1.40). Our results suggested that poor oral hygiene is not only a risk factor but may also be a prognostic factor of HNC.

AB - Poor oral hygiene is an established risk factor of head and neck cancer (HNC); however, its role in the survival of HNC patients is unclear. This study evaluated the association between oral hygiene habits, including regular dental visits, frequency of tooth brushing, and use of dental floss, and the overall survival (OS) of HNC patients using interview data collected from 740 HNC patients. In addition, the interactions between oral hygiene and the polymorphisms of TLR2 and TLR4 on the OS of HNC patients were assessed. The analysis indicated that poor oral hygiene was significantly associated with poorer OS of HNC patients (hazard ratio (HR) = 1.38, 95% confidence interval (CI): 1.03-1.86). This association was modified by a single nucleotide polymorphism, rs11536889, of TLR4. A significant association between poor oral hygiene and worse survival of HNC was observed among those with the CG or CC genotype (HR = 2.32, 95% CI: 1.41-3.82) but not among those with the GG genotype (HR = 0.95, 95% CI: 0.65-1.40). Our results suggested that poor oral hygiene is not only a risk factor but may also be a prognostic factor of HNC.

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KW - gene–environmental interaction

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KW - survival

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JF - Cancer Medicine

IS - 4

ER -

Oral hygiene and the overall survival of head and neck cancer patients

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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