Oral adsorbent AST-120 potentiates the effect of erythropoietin-stimulating agents on Stage 5 chronic kidney disease patients: A randomized crossover study

I. Wen Wu; Kuang Hung Hsu; Chio Yin Sun; Chi Jen Tsai; Mai-Szu Wu; Chin Chan Lee

doi:10.1093/ndt/gfu061

Oral adsorbent AST-120 potentiates the effect of erythropoietin-stimulating agents on Stage 5 chronic kidney disease patients: A randomized crossover study

I. Wen Wu, Kuang Hung Hsu, Chio Yin Sun, Chi Jen Tsai, Mai-Szu Wu, Chin Chan Lee

Research output: Contribution to journal › Article › peer-review

42 Citations (Scopus)

Abstract

Background. Indoxyl sulfate (IS) suppresses erythropoietin (EPO) activity and exerts renal damage. The oral adsorbent AST-120 reduces IS load and has antioxidant and renoprotective properties; however, its roles in the treatment of anemia remain unclear in chronic kidney disease (CKD) patients. Methods. Fifty-one Stage 5 predialysis CKD patients with hemoglobin

Original language	English
Pages (from-to)	1719-1727
Number of pages	9
Journal	Nephrology Dialysis Transplantation
Volume	29
Issue number	9
DOIs	https://doi.org/10.1093/ndt/gfu061
Publication status	Published - Sept 2014

Keywords

Anemia
Carbonaceous adsorbents
Chronic kidney disease
Uremic toxins

ASJC Scopus subject areas

Nephrology
Transplantation

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10.1093/ndt/gfu061

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abstract = "Background. Indoxyl sulfate (IS) suppresses erythropoietin (EPO) activity and exerts renal damage. The oral adsorbent AST-120 reduces IS load and has antioxidant and renoprotective properties; however, its roles in the treatment of anemia remain unclear in chronic kidney disease (CKD) patients. Methods. Fifty-one Stage 5 predialysis CKD patients with hemoglobin ",

keywords = "Anemia, Carbonaceous adsorbents, Chronic kidney disease, Uremic toxins",

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AU - Hsu, Kuang Hung

AU - Sun, Chio Yin

AU - Tsai, Chi Jen

AU - Wu, Mai-Szu

AU - Lee, Chin Chan

PY - 2014/9

Y1 - 2014/9

N2 - Background. Indoxyl sulfate (IS) suppresses erythropoietin (EPO) activity and exerts renal damage. The oral adsorbent AST-120 reduces IS load and has antioxidant and renoprotective properties; however, its roles in the treatment of anemia remain unclear in chronic kidney disease (CKD) patients. Methods. Fifty-one Stage 5 predialysis CKD patients with hemoglobin

AB - Background. Indoxyl sulfate (IS) suppresses erythropoietin (EPO) activity and exerts renal damage. The oral adsorbent AST-120 reduces IS load and has antioxidant and renoprotective properties; however, its roles in the treatment of anemia remain unclear in chronic kidney disease (CKD) patients. Methods. Fifty-one Stage 5 predialysis CKD patients with hemoglobin

KW - Anemia

KW - Carbonaceous adsorbents

KW - Chronic kidney disease

KW - Uremic toxins

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Oral adsorbent AST-120 potentiates the effect of erythropoietin-stimulating agents on Stage 5 chronic kidney disease patients: A randomized crossover study

Abstract

Keywords

ASJC Scopus subject areas

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