ORAI1 genetic polymorphisms associated with the susceptibility of atopic dermatitis in Japanese and Taiwanese populations

Wei-Chiao Chang; Chih-Hung Lee; Tomomitsu Hirota; Li-Fang Wang; Satoru Doi; Akihiko Miyatake; Tadao Enomoto; Kaori Tomita; Masafumi Sakashita; Takechiyo Yamada; Shigeharu Fujieda; Koji Ebe; Hidehisa Saeki; Satoshi Takeuchi; Masutaka Furue; Wei-Chiao Chen; Yi-Ching Chiu; Wei Pin Chang; Chien-Hui Hong; Edward Hsi; Suh-Hang Hank Juo; Hsin-Su Yu; Yusuke Nakamura; Mayumi Tamari

doi:10.1371/journal.pone.0029387

ORAI1 genetic polymorphisms associated with the susceptibility of atopic dermatitis in Japanese and Taiwanese populations

Wei-Chiao Chang, Chih-Hung Lee, Tomomitsu Hirota, Li-Fang Wang, Satoru Doi, Akihiko Miyatake, Tadao Enomoto, Kaori Tomita, Masafumi Sakashita, Takechiyo Yamada, Shigeharu Fujieda, Koji Ebe, Hidehisa Saeki, Satoshi Takeuchi, Masutaka Furue, Wei-Chiao Chen, Yi-Ching Chiu, Wei Pin Chang, Chien-Hui Hong, Edward HsiSuh-Hang Hank Juo, Hsin-Su Yu, Yusuke Nakamura, Mayumi Tamari

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Abstract

Atopic dermatitis is a chronic inflammatory skin disease. Multiple genetic and environmental factors are thought to be responsible for susceptibility to AD. In this study, we collected 2,478 DNA samples including 209 AD patients and 729 control subjects from Taiwanese population and 513 AD patients and 1027 control subject from Japanese population for sequencing and genotyping ORAI1. A total of 14 genetic variants including 3 novel single-nucleotide polymorphisms (SNPs) in the ORAI1 gene were identified. Our results indicated that a non-synonymous SNP (rs3741596, Ser218Gly) associated with the susceptibility of AD in the Japanese population but not in the Taiwanese population. However, there is another SNP of ORAI1 (rs3741595) associated with the risk of AD in the Taiwanese population but not in the Japanese population. Taken together, our results indicated that genetic polymorphisms of ORAI1 are very likely to be involved in the susceptibility of AD.

Original language	English
Article number	e29387
Journal	PLoS ONE
Volume	7
Issue number	1
DOIs	https://doi.org/10.1371/journal.pone.0029387
Publication status	Published - Jan 13 2012
Externally published	Yes

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Chang, W.-C., Lee, C.-H., Hirota, T., Wang, L.-F., Doi, S., Miyatake, A., Enomoto, T., Tomita, K., Sakashita, M., Yamada, T., Fujieda, S., Ebe, K., Saeki, H., Takeuchi, S., Furue, M., Chen, W.-C., Chiu, Y.-C., Chang, W. P., Hong, C.-H., ... Tamari, M. (2012). ORAI1 genetic polymorphisms associated with the susceptibility of atopic dermatitis in Japanese and Taiwanese populations. PLoS ONE, 7(1), Article e29387. https://doi.org/10.1371/journal.pone.0029387

Chang, W-C, Lee, C-H, Hirota, T, Wang, L-F, Doi, S, Miyatake, A, Enomoto, T, Tomita, K, Sakashita, M, Yamada, T, Fujieda, S, Ebe, K, Saeki, H, Takeuchi, S, Furue, M, Chen, W-C, Chiu, Y-C, Chang, WP, Hong, C-H, Hsi, E, Juo, S-HH, Yu, H-S, Nakamura, Y & Tamari, M 2012, 'ORAI1 genetic polymorphisms associated with the susceptibility of atopic dermatitis in Japanese and Taiwanese populations', PLoS ONE, vol. 7, no. 1, e29387. https://doi.org/10.1371/journal.pone.0029387

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abstract = "Atopic dermatitis is a chronic inflammatory skin disease. Multiple genetic and environmental factors are thought to be responsible for susceptibility to AD. In this study, we collected 2,478 DNA samples including 209 AD patients and 729 control subjects from Taiwanese population and 513 AD patients and 1027 control subject from Japanese population for sequencing and genotyping ORAI1. A total of 14 genetic variants including 3 novel single-nucleotide polymorphisms (SNPs) in the ORAI1 gene were identified. Our results indicated that a non-synonymous SNP (rs3741596, Ser218Gly) associated with the susceptibility of AD in the Japanese population but not in the Taiwanese population. However, there is another SNP of ORAI1 (rs3741595) associated with the risk of AD in the Taiwanese population but not in the Japanese population. Taken together, our results indicated that genetic polymorphisms of ORAI1 are very likely to be involved in the susceptibility of AD.",

author = "Wei-Chiao Chang and Chih-Hung Lee and Tomomitsu Hirota and Li-Fang Wang and Satoru Doi and Akihiko Miyatake and Tadao Enomoto and Kaori Tomita and Masafumi Sakashita and Takechiyo Yamada and Shigeharu Fujieda and Koji Ebe and Hidehisa Saeki and Satoshi Takeuchi and Masutaka Furue and Wei-Chiao Chen and Yi-Ching Chiu and Chang, {Wei Pin} and Chien-Hui Hong and Edward Hsi and Juo, {Suh-Hang Hank} and Hsin-Su Yu and Yusuke Nakamura and Mayumi Tamari",

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AU - Chang, Wei-Chiao

AU - Lee, Chih-Hung

AU - Hirota, Tomomitsu

AU - Wang, Li-Fang

AU - Doi, Satoru

AU - Miyatake, Akihiko

AU - Enomoto, Tadao

AU - Tomita, Kaori

AU - Sakashita, Masafumi

AU - Yamada, Takechiyo

AU - Fujieda, Shigeharu

AU - Ebe, Koji

AU - Saeki, Hidehisa

AU - Takeuchi, Satoshi

AU - Furue, Masutaka

AU - Chen, Wei-Chiao

AU - Chiu, Yi-Ching

AU - Chang, Wei Pin

AU - Hong, Chien-Hui

AU - Hsi, Edward

AU - Juo, Suh-Hang Hank

AU - Yu, Hsin-Su

AU - Nakamura, Yusuke

AU - Tamari, Mayumi

PY - 2012/1/13

Y1 - 2012/1/13

N2 - Atopic dermatitis is a chronic inflammatory skin disease. Multiple genetic and environmental factors are thought to be responsible for susceptibility to AD. In this study, we collected 2,478 DNA samples including 209 AD patients and 729 control subjects from Taiwanese population and 513 AD patients and 1027 control subject from Japanese population for sequencing and genotyping ORAI1. A total of 14 genetic variants including 3 novel single-nucleotide polymorphisms (SNPs) in the ORAI1 gene were identified. Our results indicated that a non-synonymous SNP (rs3741596, Ser218Gly) associated with the susceptibility of AD in the Japanese population but not in the Taiwanese population. However, there is another SNP of ORAI1 (rs3741595) associated with the risk of AD in the Taiwanese population but not in the Japanese population. Taken together, our results indicated that genetic polymorphisms of ORAI1 are very likely to be involved in the susceptibility of AD.

AB - Atopic dermatitis is a chronic inflammatory skin disease. Multiple genetic and environmental factors are thought to be responsible for susceptibility to AD. In this study, we collected 2,478 DNA samples including 209 AD patients and 729 control subjects from Taiwanese population and 513 AD patients and 1027 control subject from Japanese population for sequencing and genotyping ORAI1. A total of 14 genetic variants including 3 novel single-nucleotide polymorphisms (SNPs) in the ORAI1 gene were identified. Our results indicated that a non-synonymous SNP (rs3741596, Ser218Gly) associated with the susceptibility of AD in the Japanese population but not in the Taiwanese population. However, there is another SNP of ORAI1 (rs3741595) associated with the risk of AD in the Taiwanese population but not in the Japanese population. Taken together, our results indicated that genetic polymorphisms of ORAI1 are very likely to be involved in the susceptibility of AD.

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ORAI1 genetic polymorphisms associated with the susceptibility of atopic dermatitis in Japanese and Taiwanese populations

Abstract

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