@inproceedings{c63c9d5c31194935ae4d71fa1b09c66f,
title = "Optimal design of microneedles inserts into skin by numerical simulation",
abstract = "The purpose of this research is to find the optimal design for biodegradable polymer microneedle patches. Based on the mechanical properties of different skin layers and the failure criterion of the material, this research designs a microneedle of four types and three sizes, then discusses the insertion force and the variation of stress during the process of PLA microneedle insertion into skin by numerical simulation. This research uses the dynamic finite element software ANSYS / LS-DYNA to simulate the processing for PLA microneedle inserts into skin. The master microneedle array was fabricated by the MEMS process. This research uses PDMS to fabricate the mould for microneedles. Finally, a biodegradable polymer polylactic acid (PLA) microneedle patch was fabricated using a PDMS mould micro hot embossing method.",
keywords = "Numerical simulation, Optimal design, PLA microneedle",
author = "Chiu, {Chui Yu} and Kuo, {Hsin Chuan} and Yi Lin and Lee, {Jeou Long} and Shen, {Yung Kang} and Kang, {Sheng Jie}",
year = "2012",
doi = "10.4028/www.scientific.net/KEM.516.624",
language = "English",
isbn = "9783037854280",
volume = "516",
series = "Key Engineering Materials",
pages = "624--628",
booktitle = "Key Engineering Materials",
note = "4th International Conference of Asian Society for Precision Engineering and Nanotechnology, ASPEN 2011 ; Conference date: 16-11-2011 Through 18-11-2011",
}