One-year post-hospital medical costs and relapse rates of bipolar disorder patients in Taiwan: A population-based study

Chao Hsiun Tang, Ming H. Hsieh, Sheng Tzu Hung, I. Hui Lee, Yung Jung Lin, Yen Kuang Yang

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)


Objectives: We examined a nationwide population-based dataset of patients with bipolar disorder (BD) hospitalized in Taiwan, with our analyses focusing on one-year medical costs and relapse rates.Methods: The data for this study, covering the years 2006 and 2007, were obtained from the Taiwan National Health Insurance (NHI) claims database. The study sample comprised BD patients who were discharged from hospitals between January 1 and December 31, 2006. Annual medical costs and relapse rates were described; the Kaplan-Meier method and the generalized linear models were carried out to examine the risk factors associated with cases of relapse.Results: The annual medical costs associated with relapses among the study sample were found to be approximately 7.6 times the average per-capita NHI expenditure in Taiwan in 2006 (US$4,354 versus US$574), with a one-year relapse rate of 55%. Those patients between 20 and 60 years old with a medication possession ratio of <80 and with depressive episodes during the recruitment period were identified as being at risk of relapse.Conclusion: Bipolar disorder, which is a very costly disease, is associated with both poor medication adherence rates and frequent recurrences. Targeting drug adherence issues during maintenance treatment may well provide a valuable opportunity to reduce the risk of such recurrences.

Original languageEnglish
Pages (from-to)859-865
Number of pages7
JournalBipolar Disorders
Issue number8
Publication statusPublished - Dec 2010


  • Bipolar disorder
  • Medical costs
  • Medication possession ratio (MPR)
  • Relapse

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry


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