One-pot synthesis of luotonin A and its analogues

Ming Chung Tseng, Yu Wan Chu, Hsiang Ping Tsai, Chun Mao Lin, Jaulang Hwang, Yen Ho Chu

Research output: Contribution to journalArticlepeer-review

74 Citations (Scopus)


Starting with inexpensive reagents, a self-directed chemical process with the aid of a single metal triflate was readily achieved to concomitantly construct quinazoline and pyrroloquinoline cores to afford the synthesis of luotonin A and its analogues. Among all compounds prepared, 2c, 2d, and 3b exhibit more potent inhibitory activity than luotonin A against human topoisomerase I.(Figure Presented)

Original languageEnglish
Pages (from-to)920-923
Number of pages4
JournalOrganic Letters
Issue number5
Publication statusPublished - Mar 4 2011

ASJC Scopus subject areas

  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Biochemistry


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