One-pot synthesis of luotonin A and its analogues

Ming Chung Tseng; Yu Wan Chu; Hsiang Ping Tsai; Chun Mao Lin; Jaulang Hwang; Yen Ho Chu

doi:10.1021/ol1029707

One-pot synthesis of luotonin A and its analogues

Ming Chung Tseng, Yu Wan Chu, Hsiang Ping Tsai, Chun Mao Lin, Jaulang Hwang, Yen Ho Chu

Research output: Contribution to journal › Article › peer-review

77 Citations (Scopus)

Abstract

Starting with inexpensive reagents, a self-directed chemical process with the aid of a single metal triflate was readily achieved to concomitantly construct quinazoline and pyrroloquinoline cores to afford the synthesis of luotonin A and its analogues. Among all compounds prepared, 2c, 2d, and 3b exhibit more potent inhibitory activity than luotonin A against human topoisomerase I.(Figure Presented)

Original language	English
Pages (from-to)	920-923
Number of pages	4
Journal	Organic Letters
Volume	13
Issue number	5
DOIs	https://doi.org/10.1021/ol1029707
Publication status	Published - Mar 4 2011

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

Access to Document

10.1021/ol1029707

Cite this

@article{fa233127689d495c9b5e4c7906047b53,

title = "One-pot synthesis of luotonin A and its analogues",

abstract = "Starting with inexpensive reagents, a self-directed chemical process with the aid of a single metal triflate was readily achieved to concomitantly construct quinazoline and pyrroloquinoline cores to afford the synthesis of luotonin A and its analogues. Among all compounds prepared, 2c, 2d, and 3b exhibit more potent inhibitory activity than luotonin A against human topoisomerase I.(Figure Presented)",

author = "Tseng, {Ming Chung} and Chu, {Yu Wan} and Tsai, {Hsiang Ping} and Lin, {Chun Mao} and Jaulang Hwang and Chu, {Yen Ho}",

year = "2011",

month = mar,

day = "4",

doi = "10.1021/ol1029707",

language = "English",

volume = "13",

pages = "920--923",

journal = "Organic Letters",

issn = "1523-7060",

publisher = "American Chemical Society",

number = "5",

}

TY - JOUR

T1 - One-pot synthesis of luotonin A and its analogues

AU - Tseng, Ming Chung

AU - Chu, Yu Wan

AU - Tsai, Hsiang Ping

AU - Lin, Chun Mao

AU - Hwang, Jaulang

AU - Chu, Yen Ho

PY - 2011/3/4

Y1 - 2011/3/4

N2 - Starting with inexpensive reagents, a self-directed chemical process with the aid of a single metal triflate was readily achieved to concomitantly construct quinazoline and pyrroloquinoline cores to afford the synthesis of luotonin A and its analogues. Among all compounds prepared, 2c, 2d, and 3b exhibit more potent inhibitory activity than luotonin A against human topoisomerase I.(Figure Presented)

AB - Starting with inexpensive reagents, a self-directed chemical process with the aid of a single metal triflate was readily achieved to concomitantly construct quinazoline and pyrroloquinoline cores to afford the synthesis of luotonin A and its analogues. Among all compounds prepared, 2c, 2d, and 3b exhibit more potent inhibitory activity than luotonin A against human topoisomerase I.(Figure Presented)

UR - http://www.scopus.com/inward/record.url?scp=79952169655&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79952169655&partnerID=8YFLogxK

U2 - 10.1021/ol1029707

DO - 10.1021/ol1029707

M3 - Article

C2 - 21268635

AN - SCOPUS:79952169655

SN - 1523-7060

VL - 13

SP - 920

EP - 923

JO - Organic Letters

JF - Organic Letters

IS - 5

ER -

One-pot synthesis of luotonin A and its analogues

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this